Genome-wide association studies in cancer

被引：173

作者：

Easton, Douglas F. ^{[1
]}

Eeles, Rosalind A. ^{[2
,3
,4
]}

机构：

[1] Univ Cambridge, Strangeways Res Lab, Canc Res UK Genet Epidemiol Unit, Cambridge CB1 8RN, England

[2] Inst Canc Res, Translat Canc Genet Team, Sutton SM2 5NG, Surrey, England

[3] Royal Marsden NHS Fdn Trust, Sutton SM2 5NG, Surrey, England

[4] Royal Marsden NHS Fdn Trust, London SW3 6JJ, England

来源：

HUMAN MOLECULAR GENETICS | 2008年 / 17卷

关键词：

D O I：

10.1093/hmg/ddn287

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Genome-wide association studies (GWAS) provide a powerful approach to identify common, low-penetrance disease loci without prior knowledge of location or function. GWAS have been conducted in five of the commonest cancer types: breast, prostate, colorectal and lung, and melanoma, and have identified more than 20 novel disease loci, confirming that susceptibility to these diseases is polygenic. Many of these loci were detected at low power, indicating that many further loci will probably be detected with larger studies. For the most part, the loci were not previously suspected to be related to carcinogenesis, and point to new disease mechanisms. The risks conferred by the susceptibility alleles are low, generally 1.3-fold or less. The combined effects may, however, be sufficiently large to be useful for risk prediction, and targeted screening and prevention, particularly as more loci are identified.

引用

页码：R109 / R115

页数：7

共 58 条

[1]

ADNANE J, 1991, ONCOGENE, V6, P659

[2] Inherited variants of MYH associated with somatic G:C→T:A mutations in colorectal tumors [J].

Al-Tassan, N ;

Chmiel, NH ;

Maynard, J ;

Fleming, N ;

Livingston, AL ;

Williams, GT ;

Hodges, AK ;

Davies, DR ;

David, SS ;

Sampson, JR ;

Cheadle, JR .

NATURE GENETICS, 2002, 30 (02) :227-232

[3] Genome-wide association scan of tag SNPs identifies a susceptibility locus for lung cancer at 15q25.1 [J].

Amos, Christopher I. ;

Wu, Xifeng ;

Broderick, Peter ;

Gorlov, Ivan P. ;

Gu, Jian ;

Eisen, Timothy ;

Dong, Qiong ;

Zhang, Qing ;

Gu, Xiangjun ;

Vijayakrishnan, Jayaram ;

Sullivan, Kate ;

Matakidou, Athena ;

Wang, Yufei ;

Mills, Gordon ;

Doheny, Kimberly ;

Tsai, Ya-Yu ;

Chen, Wei Vivien ;

Shete, Sanjay ;

Spitz, Margaret R. ;

Houlston, Richard S. .

NATURE GENETICS, 2008, 40 (05) :616-622

[4] A common variant associated with prostate cancer in European and African populations [J].

Amundadottir, Laufey T. ;

Sulem, Patrick ;

Gudmundsson, Julius ;

Helgason, Agnar ;

Baker, Adam ;

Agnarsson, Bjarni A. ;

Sigurdsson, Asgeir ;

Benediktsdottir, Kristrun R. ;

Cazier, Jean-Baptiste ;

Sainz, Jesus ;

Jakobsdottir, Margret ;

Kostic, Jelena ;

Magnusdottir, Droplaug N. ;

Ghosh, Shyamali ;

Agnarsson, Kari ;

Birgisdottir, Birgitta ;

Le Roux, Louise ;

Olafsdottir, Adalheidur ;

Blondal, Thorarinn ;

Andresdottir, Margret ;

Gretarsdottir, Olafia Svandis ;

Bergthorsson, Jon T. ;

Gudbjartsson, Daniel ;

Gylfason, Arnaldur ;

Thorleifsson, Gudmar ;

Manolescu, Andrei ;

Kristjansson, Kristleifur ;

Geirsson, Gudmundur ;

Isaksson, Helgi ;

Douglas, Julie ;

Johansson, Jan-Erik ;

Balter, Katarina ;

Wiklund, Fredrik ;

Montie, James E. ;

Yu, Xiaoying ;

Suarez, Brian K. ;

Ober, Carole ;

Cooney, Kathleen A. ;

Gronberg, Henrik ;

Catalona, William J. ;

Einarsson, Gudmundur V. ;

Barkardottir, Rosa B. ;

Gulcher, Jeffrey R. ;

Kong, Augustine ;

Thorsteinsdottir, Unnur ;

Stefansson, Kari .

NATURE GENETICS, 2006, 38 (06) :652-658

[5] Common breast cancer-predisposition alleles are associated with breast cancer risk in BRCA1 and BRCA2 mutation carriers [J].

Antoniou, Antonis C. ;

Spurdle, Amanda B. ;

Sinilnikova, Olga M. ;

Healey, Sue ;

Pooley, Karen A. ;

Schmutzler, Rita K. ;

Versmold, Beatrix ;

Engel, Christoph ;

Meindl, Alfons ;

Arnold, Norbert ;

Hofmann, Wera ;

Sutter, Christian ;

Niederacher, Dieter ;

Deissler, Helmut ;

Caldes, Trinidad ;

Kampjarvi, Kati ;

Nevanlinna, Heli ;

Simard, Jacques ;

Beesley, Jonathan ;

Chen, Xiaoqing ;

Neuhausen, Susan L. ;

Rebbeck, Timothy R. ;

Wagner, Theresa ;

Lynch, Henry T. ;

Isaacs, Claudine ;

Weitzel, Jeffrey ;

Ganz, Patricia A. ;

Daly, Mary B. ;

Tomlinson, Gail ;

Olopade, Olufunmilayo I. ;

Bium, Joanne L. ;

Couch, Fergus J. ;

Peterlongo, Paolo ;

Manoukian, Siranoush ;

Barile, Monica ;

Radice, Paolo ;

Szabo, Csilla I. ;

Pereira, Lutecia H. Mateus ;

Greene, Mark H. ;

Rennert, Gad ;

Leibkowicz, Flavio ;

Barnett-Griness, Ofra ;

Andrulis, Irene L. ;

Ozcelik, Hilmi ;

Gerdes, Anne-Marie ;

Caligo, Maria A. ;

Laitman, Yael ;

Kaufman, Bella ;

Milgrom, Roni ;

Friedman, Eitan .

AMERICAN JOURNAL OF HUMAN GENETICS, 2008, 82 (04) :937-948

[6] A genome-wide association study shows that common alleles of SMAD7 influence colorectal cancer risk [J].

Broderick, Peter ;

Carvajal-Carmona, Luis ;

Pittman, Alan M. ;

Webb, Emily ;

Howarth, Kimberley ;

Rowan, Andrew ;

Lubbe, Steven ;

Spain, Sarah ;

Sullivan, Kate ;

Fielding, Sarah ;

Jaeger, Emma ;

Vijayakrishnan, Jayaram ;

Kemp, Zoe ;

Gorman, Maggie ;

Chandler, Ian ;

Papaemmanuil, Elli ;

Penegar, Steven ;

Wood, Wendy ;

Sellick, Gabrielle ;

Qureshi, Mobshra ;

Teixeira, Ana ;

Domingo, Enric ;

Barclay, Ella ;

Martin, Lynn ;

Sieber, Oliver ;

Kerr, David ;

Gray, Richard ;

Peto, Julian ;

Cazier, Jean-Baptiste ;

Tomlinson, Ian ;

Houlston, Richard S. .

NATURE GENETICS, 2007, 39 (11) :1315-1317

[7] Common sequence variants on 20q11.22 confer melanoma susceptibility [J].

Brown, Kevin M. ;

MacGregor, Stuart ;

Montgomery, Grant W. ;

Craig, David W. ;

Zhao, Zhen Zhen ;

Iyadurai, Kelly ;

Henders, Anjali K. ;

Homer, Nils ;

Campbell, Megan J. ;

Stark, Mitchell ;

Thomas, Shane ;

Schmid, Helen ;

Holland, Elizabeth A. ;

Gillanders, Elizabeth M. ;

Duffy, David L. ;

Maskiell, Judith A. ;

Jetann, Jodie ;

Ferguson, Megan ;

Stephan, Dietrich A. ;

Cust, Anne E. ;

Whiteman, David ;

Green, Adele ;

Olsson, Hakan ;

Puig, Susana ;

Ghiorzo, Paola ;

Hansson, Johan ;

Demenais, Florence ;

Goldstein, Alisa M. ;

Gruis, Nelleke A. ;

Elder, David E. ;

Bishop, Julia Newton ;

Kefford, Richard F. ;

Giles, Graham G. ;

Armstrong, Bruce K. ;

Aitken, Joanne F. ;

Hopper, John L. ;

Martin, Nicholas G. ;

Trent, Jeffrey M. ;

Mann, Graham J. ;

Hayward, Nicholas K. .

NATURE GENETICS, 2008, 40 (07) :838-840

[8] Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls [J].

Burton, Paul R. ;

Clayton, David G. ;

Cardon, Lon R. ;

Craddock, Nick ;

Deloukas, Panos ;

Duncanson, Audrey ;

Kwiatkowski, Dominic P. ;

McCarthy, Mark I. ;

Ouwehand, Willem H. ;

Samani, Nilesh J. ;

Todd, John A. ;

Donnelly, Peter ;

Barrett, Jeffrey C. ;

Davison, Dan ;

Easton, Doug ;

Evans, David ;

Leung, Hin-Tak ;

Marchini, Jonathan L. ;

Morris, Andrew P. ;

Spencer, Chris C. A. ;

Tobin, Martin D. ;

Attwood, Antony P. ;

Boorman, James P. ;

Cant, Barbara ;

Everson, Ursula ;

Hussey, Judith M. ;

Jolley, Jennifer D. ;

Knight, Alexandra S. ;

Koch, Kerstin ;

Meech, Elizabeth ;

Nutland, Sarah ;

Prowse, Christopher V. ;

Stevens, Helen E. ;

Taylor, Niall C. ;

Walters, Graham R. ;

Walker, Neil M. ;

Watkins, Nicholas A. ;

Winzer, Thilo ;

Jones, Richard W. ;

McArdle, Wendy L. ;

Ring, Susan M. ;

Strachan, David P. ;

Pembrey, Marcus ;

Breen, Gerome ;

St Clair, David ;

Caesar, Sian ;

Gordon-Smith, Katherine ;

Jones, Lisa ;

Fraser, Christine ;

Green, Elain K. .

NATURE, 2007, 447 (7145) :661-678

[9] A common coding variant in CASP8 is associated with breast cancer risk [J].

Cox, Angela ;

Dunning, Alison M. ;

Garcia-Closas, Montserrat ;

Balasubramanian, Sabapathy ;

Reed, Malcolm W. R. ;

Pooley, Karen A. ;

Scollen, Serena ;

Baynes, Caroline ;

Ponder, Bruce A. J. ;

Chanock, Stephen ;

Lissowska, Jolanta ;

Brinton, Louise ;

Peplonska, Beata ;

Southey, Melissa C. ;

Hopper, John L. ;

McCredie, Margaret R. E. ;

Giles, Graham G. ;

Fletcher, Olivia ;

Johnson, Nichola ;

dos Santos Silva, Isabel ;

Gibson, Lorna ;

Bojesen, Stig E. ;

Nordestgaard, Borge G. ;

Axelsson, Christen K. ;

Torres, Diana ;

Hamann, Ute ;

Justenhoven, Christina ;

Brauch, Hiltrud ;

Chang-Claude, Jenny ;

Kropp, Silke ;

Risch, Angela ;

Wang-Gohrke, Shan ;

Schuermann, Peter ;

Bogdanova, Natalia ;

Doerk, Thilo ;

Fagerholm, Rainer ;

Aaltonen, Kirsimari ;

Blomqvist, Carl ;

Nevanlinna, Heli ;

Seal, Sheila ;

Renwick, Anthony ;

Stratton, Michael R. ;

Rahman, Nazneen ;

Sangrajrang, Suleeporn ;

Hughes, David ;

Odefrey, Fabrice ;

Brennan, Paul ;

Spurdle, Amanda B. ;

Chenevix-Trench, Georgia ;

Beesley, Jonathan .

NATURE GENETICS, 2007, 39 (03) :352-358

[10] Genome-wide association study identifies novel breast cancer susceptibility loci [J].

Easton, Douglas F. ;

Pooley, Karen A. ;

Dunning, Alison M. ;

Pharoah, Paul D. P. ;

Thompson, Deborah ;

Ballinger, Dennis G. ;

Struewing, Jeffery P. ;

Morrison, Jonathan ;

Field, Helen ;

Luben, Robert ;

Wareham, Nicholas ;

Ahmed, Shahana ;

Healey, Catherine S. ;

Bowman, Richard ;

Meyer, Kerstin B. ;

Haiman, Christopher A. ;

Kolonel, Laurence K. ;

Henderson, Brian E. ;

Le Marchand, Loic ;

Brennan, Paul ;

Sangrajrang, Suleeporn ;

Gaborieau, Valerie ;

Odefrey, Fabrice ;

Shen, Chen-Yang ;

Wu, Pei-Ei ;

Wang, Hui-Chun ;

Eccles, Diana ;

Evans, D. Gareth ;

Peto, Julian ;

Fletcher, Olivia ;

Johnson, Nichola ;

Seal, Sheila ;

Stratton, Michael R. ;

Rahman, Nazneen ;

Chenevix-Trench, Georgia ;

Bojesen, Stig E. ;

Nordestgaard, Borge G. ;

Axelsson, Christen K. ;

Garcia-Closas, Montserrat ;

Brinton, Louise ;

Chanock, Stephen ;

Lissowska, Jolanta ;

Peplonska, Beata ;

Nevanlinna, Heli ;

Fagerholm, Rainer ;

Eerola, Hannaleena ;

Kang, Daehee ;

Yoo, Keun-Young ;

Noh, Dong-Young ;

Ahn, Sei-Hyun .

NATURE, 2007, 447 (7148) :1087-U7

← 1 2 3 4 5 6 →

共 58 条

[1]

ADNANE J, 1991, ONCOGENE, V6, P659

[2] Inherited variants of MYH associated with somatic G:C→T:A mutations in colorectal tumors [J].

Al-Tassan, N ;

Chmiel, NH ;

Maynard, J ;

Fleming, N ;

Livingston, AL ;

Williams, GT ;

Hodges, AK ;

Davies, DR ;

David, SS ;

Sampson, JR ;

Cheadle, JR .

NATURE GENETICS, 2002, 30 (02) :227-232

[3] Genome-wide association scan of tag SNPs identifies a susceptibility locus for lung cancer at 15q25.1 [J].

Amos, Christopher I. ;

Wu, Xifeng ;

Broderick, Peter ;

Gorlov, Ivan P. ;

Gu, Jian ;

Eisen, Timothy ;

Dong, Qiong ;

Zhang, Qing ;

Gu, Xiangjun ;

Vijayakrishnan, Jayaram ;

Sullivan, Kate ;

Matakidou, Athena ;

Wang, Yufei ;

Mills, Gordon ;

Doheny, Kimberly ;

Tsai, Ya-Yu ;

Chen, Wei Vivien ;

Shete, Sanjay ;

Spitz, Margaret R. ;

Houlston, Richard S. .

NATURE GENETICS, 2008, 40 (05) :616-622

[4] A common variant associated with prostate cancer in European and African populations [J].

Amundadottir, Laufey T. ;

Sulem, Patrick ;

Gudmundsson, Julius ;

Helgason, Agnar ;

Baker, Adam ;

Agnarsson, Bjarni A. ;

Sigurdsson, Asgeir ;

Benediktsdottir, Kristrun R. ;

Cazier, Jean-Baptiste ;

Sainz, Jesus ;

Jakobsdottir, Margret ;

Kostic, Jelena ;

Magnusdottir, Droplaug N. ;

Ghosh, Shyamali ;

Agnarsson, Kari ;

Birgisdottir, Birgitta ;

Le Roux, Louise ;

Olafsdottir, Adalheidur ;

Blondal, Thorarinn ;

Andresdottir, Margret ;

Gretarsdottir, Olafia Svandis ;

Bergthorsson, Jon T. ;

Gudbjartsson, Daniel ;

Gylfason, Arnaldur ;

Thorleifsson, Gudmar ;

Manolescu, Andrei ;

Kristjansson, Kristleifur ;

Geirsson, Gudmundur ;

Isaksson, Helgi ;

Douglas, Julie ;

Johansson, Jan-Erik ;

Balter, Katarina ;

Wiklund, Fredrik ;

Montie, James E. ;

Yu, Xiaoying ;

Suarez, Brian K. ;

Ober, Carole ;

Cooney, Kathleen A. ;

Gronberg, Henrik ;

Catalona, William J. ;

Einarsson, Gudmundur V. ;

Barkardottir, Rosa B. ;

Gulcher, Jeffrey R. ;

Kong, Augustine ;

Thorsteinsdottir, Unnur ;

Stefansson, Kari .

NATURE GENETICS, 2006, 38 (06) :652-658

[5] Common breast cancer-predisposition alleles are associated with breast cancer risk in BRCA1 and BRCA2 mutation carriers [J].

Antoniou, Antonis C. ;

Spurdle, Amanda B. ;

Sinilnikova, Olga M. ;

Healey, Sue ;

Pooley, Karen A. ;

Schmutzler, Rita K. ;

Versmold, Beatrix ;

Engel, Christoph ;

Meindl, Alfons ;

Arnold, Norbert ;

Hofmann, Wera ;

Sutter, Christian ;

Niederacher, Dieter ;

Deissler, Helmut ;

Caldes, Trinidad ;

Kampjarvi, Kati ;

Nevanlinna, Heli ;

Simard, Jacques ;

Beesley, Jonathan ;

Chen, Xiaoqing ;

Neuhausen, Susan L. ;

Rebbeck, Timothy R. ;

Wagner, Theresa ;

Lynch, Henry T. ;

Isaacs, Claudine ;

Weitzel, Jeffrey ;

Ganz, Patricia A. ;

Daly, Mary B. ;

Tomlinson, Gail ;

Olopade, Olufunmilayo I. ;

Bium, Joanne L. ;

Couch, Fergus J. ;

Peterlongo, Paolo ;

Manoukian, Siranoush ;

Barile, Monica ;

Radice, Paolo ;

Szabo, Csilla I. ;

Pereira, Lutecia H. Mateus ;

Greene, Mark H. ;

Rennert, Gad ;

Leibkowicz, Flavio ;

Barnett-Griness, Ofra ;

Andrulis, Irene L. ;

Ozcelik, Hilmi ;

Gerdes, Anne-Marie ;

Caligo, Maria A. ;

Laitman, Yael ;

Kaufman, Bella ;

Milgrom, Roni ;

Friedman, Eitan .

AMERICAN JOURNAL OF HUMAN GENETICS, 2008, 82 (04) :937-948

[6] A genome-wide association study shows that common alleles of SMAD7 influence colorectal cancer risk [J].

Broderick, Peter ;

Carvajal-Carmona, Luis ;

Pittman, Alan M. ;

Webb, Emily ;

Howarth, Kimberley ;

Rowan, Andrew ;

Lubbe, Steven ;

Spain, Sarah ;

Sullivan, Kate ;

Fielding, Sarah ;

Jaeger, Emma ;

Vijayakrishnan, Jayaram ;

Kemp, Zoe ;

Gorman, Maggie ;

Chandler, Ian ;

Papaemmanuil, Elli ;

Penegar, Steven ;

Wood, Wendy ;

Sellick, Gabrielle ;

Qureshi, Mobshra ;

Teixeira, Ana ;

Domingo, Enric ;

Barclay, Ella ;

Martin, Lynn ;

Sieber, Oliver ;

Kerr, David ;

Gray, Richard ;

Peto, Julian ;

Cazier, Jean-Baptiste ;

Tomlinson, Ian ;

Houlston, Richard S. .

NATURE GENETICS, 2007, 39 (11) :1315-1317

[7] Common sequence variants on 20q11.22 confer melanoma susceptibility [J].

Brown, Kevin M. ;

MacGregor, Stuart ;

Montgomery, Grant W. ;

Craig, David W. ;

Zhao, Zhen Zhen ;

Iyadurai, Kelly ;

Henders, Anjali K. ;

Homer, Nils ;

Campbell, Megan J. ;

Stark, Mitchell ;

Thomas, Shane ;

Schmid, Helen ;

Holland, Elizabeth A. ;

Gillanders, Elizabeth M. ;

Duffy, David L. ;

Maskiell, Judith A. ;

Jetann, Jodie ;

Ferguson, Megan ;

Stephan, Dietrich A. ;

Cust, Anne E. ;

Whiteman, David ;

Green, Adele ;

Olsson, Hakan ;

Puig, Susana ;

Ghiorzo, Paola ;

Hansson, Johan ;

Demenais, Florence ;

Goldstein, Alisa M. ;

Gruis, Nelleke A. ;

Elder, David E. ;

Bishop, Julia Newton ;

Kefford, Richard F. ;

Giles, Graham G. ;

Armstrong, Bruce K. ;

Aitken, Joanne F. ;

Hopper, John L. ;

Martin, Nicholas G. ;

Trent, Jeffrey M. ;

Mann, Graham J. ;

Hayward, Nicholas K. .

NATURE GENETICS, 2008, 40 (07) :838-840

[8] Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls [J].

Burton, Paul R. ;

Clayton, David G. ;

Cardon, Lon R. ;

Craddock, Nick ;

Deloukas, Panos ;

Duncanson, Audrey ;

Kwiatkowski, Dominic P. ;

McCarthy, Mark I. ;

Ouwehand, Willem H. ;

Samani, Nilesh J. ;

Todd, John A. ;

Donnelly, Peter ;

Barrett, Jeffrey C. ;

Davison, Dan ;

Easton, Doug ;

Evans, David ;

Leung, Hin-Tak ;

Marchini, Jonathan L. ;

Morris, Andrew P. ;

Spencer, Chris C. A. ;

Tobin, Martin D. ;

Attwood, Antony P. ;

Boorman, James P. ;

Cant, Barbara ;

Everson, Ursula ;

Hussey, Judith M. ;

Jolley, Jennifer D. ;

Knight, Alexandra S. ;

Koch, Kerstin ;

Meech, Elizabeth ;

Nutland, Sarah ;

Prowse, Christopher V. ;

Stevens, Helen E. ;

Taylor, Niall C. ;

Walters, Graham R. ;

Walker, Neil M. ;

Watkins, Nicholas A. ;

Winzer, Thilo ;

Jones, Richard W. ;

McArdle, Wendy L. ;

Ring, Susan M. ;

Strachan, David P. ;

Pembrey, Marcus ;

Breen, Gerome ;

St Clair, David ;

Caesar, Sian ;

Gordon-Smith, Katherine ;

Jones, Lisa ;

Fraser, Christine ;

Green, Elain K. .

NATURE, 2007, 447 (7145) :661-678

[9] A common coding variant in CASP8 is associated with breast cancer risk [J].

Cox, Angela ;

Dunning, Alison M. ;

Garcia-Closas, Montserrat ;

Balasubramanian, Sabapathy ;

Reed, Malcolm W. R. ;

Pooley, Karen A. ;

Scollen, Serena ;

Baynes, Caroline ;

Ponder, Bruce A. J. ;

Chanock, Stephen ;

Lissowska, Jolanta ;

Brinton, Louise ;

Peplonska, Beata ;

Southey, Melissa C. ;

Hopper, John L. ;

McCredie, Margaret R. E. ;

Giles, Graham G. ;

Fletcher, Olivia ;

Johnson, Nichola ;

dos Santos Silva, Isabel ;

Gibson, Lorna ;

Bojesen, Stig E. ;

Nordestgaard, Borge G. ;

Axelsson, Christen K. ;

Torres, Diana ;

Hamann, Ute ;

Justenhoven, Christina ;

Brauch, Hiltrud ;

Chang-Claude, Jenny ;

Kropp, Silke ;

Risch, Angela ;

Wang-Gohrke, Shan ;

Schuermann, Peter ;

Bogdanova, Natalia ;

Doerk, Thilo ;

Fagerholm, Rainer ;

Aaltonen, Kirsimari ;

Blomqvist, Carl ;

Nevanlinna, Heli ;

Seal, Sheila ;

Renwick, Anthony ;

Stratton, Michael R. ;

Rahman, Nazneen ;

Sangrajrang, Suleeporn ;

Hughes, David ;

Odefrey, Fabrice ;

Brennan, Paul ;

Spurdle, Amanda B. ;

Chenevix-Trench, Georgia ;

Beesley, Jonathan .

NATURE GENETICS, 2007, 39 (03) :352-358

[10] Genome-wide association study identifies novel breast cancer susceptibility loci [J].

Easton, Douglas F. ;

Pooley, Karen A. ;

Dunning, Alison M. ;

Pharoah, Paul D. P. ;

Thompson, Deborah ;

Ballinger, Dennis G. ;

Struewing, Jeffery P. ;

Morrison, Jonathan ;

Field, Helen ;

Luben, Robert ;

Wareham, Nicholas ;

Ahmed, Shahana ;

Healey, Catherine S. ;

Bowman, Richard ;

Meyer, Kerstin B. ;

Haiman, Christopher A. ;

Kolonel, Laurence K. ;

Henderson, Brian E. ;

Le Marchand, Loic ;

Brennan, Paul ;

Sangrajrang, Suleeporn ;

Gaborieau, Valerie ;

Odefrey, Fabrice ;

Shen, Chen-Yang ;

Wu, Pei-Ei ;

Wang, Hui-Chun ;

Eccles, Diana ;

Evans, D. Gareth ;

Peto, Julian ;

Fletcher, Olivia ;

Johnson, Nichola ;

Seal, Sheila ;

Stratton, Michael R. ;

Rahman, Nazneen ;

Chenevix-Trench, Georgia ;

Bojesen, Stig E. ;

Nordestgaard, Borge G. ;

Axelsson, Christen K. ;

Garcia-Closas, Montserrat ;

Brinton, Louise ;

Chanock, Stephen ;

Lissowska, Jolanta ;

Peplonska, Beata ;

Nevanlinna, Heli ;

Fagerholm, Rainer ;

Eerola, Hannaleena ;

Kang, Daehee ;

Yoo, Keun-Young ;

Noh, Dong-Young ;

Ahn, Sei-Hyun .

NATURE, 2007, 447 (7148) :1087-U7

← 1 2 3 4 5 6 →