Genome-wide association studies in cancer

被引：173

作者：

Easton, Douglas F. ^{[1
]}

Eeles, Rosalind A. ^{[2
,3
,4
]}

机构：

[1] Univ Cambridge, Strangeways Res Lab, Canc Res UK Genet Epidemiol Unit, Cambridge CB1 8RN, England

[2] Inst Canc Res, Translat Canc Genet Team, Sutton SM2 5NG, Surrey, England

[3] Royal Marsden NHS Fdn Trust, Sutton SM2 5NG, Surrey, England

[4] Royal Marsden NHS Fdn Trust, London SW3 6JJ, England

来源：

HUMAN MOLECULAR GENETICS | 2008年 / 17卷

关键词：

D O I：

10.1093/hmg/ddn287

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Genome-wide association studies (GWAS) provide a powerful approach to identify common, low-penetrance disease loci without prior knowledge of location or function. GWAS have been conducted in five of the commonest cancer types: breast, prostate, colorectal and lung, and melanoma, and have identified more than 20 novel disease loci, confirming that susceptibility to these diseases is polygenic. Many of these loci were detected at low power, indicating that many further loci will probably be detected with larger studies. For the most part, the loci were not previously suspected to be related to carcinogenesis, and point to new disease mechanisms. The risks conferred by the susceptibility alleles are low, generally 1.3-fold or less. The combined effects may, however, be sufficiently large to be useful for risk prediction, and targeted screening and prevention, particularly as more loci are identified.

引用

页码：R109 / R115

页数：7

共 58 条

[41] ATM mutations that cause ataxia-telangiectasia are breast cancer susceptibility alleles [J].

Renwick, Anthony ;

Thompson, Deborah ;

Seal, Sheila ;

Kelly, Patrick ;

Chagtai, Tasnim ;

Ahmed, Munaza ;

North, Bernard ;

Jayatilake, Hiran ;

Barfoot, Rita ;

Spanova, Katarina ;

McGuffog, Lesley ;

Evans, D. Gareth ;

Eccles, Diana ;

Easton, Douglas F. ;

Stratton, Michael R. ;

Rahman, Nazneen .

NATURE GENETICS, 2006, 38 (08) :873-875

[42] Truncating mutations in the Fanconi anemia J gene BRIP1 are low-penetrance breast cancer susceptibility alleles [J].

Seal, Sheila ;

Thompson, Deborah ;

Renwick, Anthony ;

Elliott, Anna ;

Kelly, Patrick ;

Barfoot, Rita ;

Chagtai, Tasnim ;

Jayatilake, Hiran ;

Ahmed, Munaza ;

Spanova, Katarina ;

North, Bernard ;

McGuffog, Lesley ;

Evans, D. Gareth ;

Eccles, Diana ;

Easton, Douglas F. ;

Stratton, Michael R. ;

Rahman, Nazneen .

NATURE GENETICS, 2006, 38 (11) :1239-1241

[43] Common variants on chromosome 5p12 confer susceptibility to estrogen receptor-positive breast cancer [J].

Stacey, Simon N. ;

Manolescu, Andrei ;

Sulem, Patrick ;

Thorlacius, Steinunn ;

Gudjonsson, Sigurjon A. ;

Jonsson, Gudbjorn F. ;

Jakobsdottir, Margret ;

Bergthorsson, Jon T. ;

Gudmundsson, Julius ;

Aben, Katja K. ;

Strobbe, Luc J. ;

Swinkels, Dorine W. ;

van Engelenburg, K. C. Anton ;

Henderson, Brian E. ;

Kolonel, Laurence N. ;

Le Marchand, Loic ;

Millastre, Esther ;

Andres, Raquel ;

Saez, Berta ;

Lambea, Julio ;

Godino, Javier ;

Polo, Eduardo ;

Tres, Alejandro ;

Picelli, Simone ;

Rantala, Johanna ;

Margolin, Sara ;

Jonsson, Thorvaldur ;

Sigurdsson, Helgi ;

Jonsdottir, Thora ;

Hrafnkelsson, Jon ;

Johannsson, Jakob ;

Sveinsson, Thorarinn ;

Myrdal, Gardar ;

Grimsson, Hlynur Niels ;

Sveinsdottir, Steinunn G. ;

Alexiusdottir, Kristin ;

Saemundsdottir, Jona ;

Sigurdsson, Asgeir ;

Kostic, Jelena ;

Gudmundsson, Larus ;

Kristjansson, Kristleifur ;

Masson, Gisli ;

Fackenthal, James D. ;

Adebamowo, Clement ;

Ogundiran, Temidayo ;

Olopade, Olufunmilayo I. ;

Haiman, Christopher A. ;

Lindblom, Annika ;

Mayordomo, Jose I. ;

Kiemeney, Lambertus A. .

NATURE GENETICS, 2008, 40 (06) :703-706

[44] Common variants on chromosomes 2q35 and 16q12 confer susceptibility to estrogen receptor-positive breast cancer [J].

Stacey, Simon N. ;

Manolescu, Andrei ;

Sulem, Patrick ;

Rafnar, Thorunn ;

Gudmundsson, Julius ;

Gudjonsson, Sigurjon A. ;

Masson, Gisli ;

Jakobsdottir, Margret ;

Thorlacius, Steinunn ;

Helgason, Agnar ;

Aben, Katja K. ;

Strobbe, Luc J. ;

Albers-Akkers, Marjo T. ;

Swinkels, Dorine W. ;

Henderson, Brian E. ;

Kolonel, Laurence N. ;

Le Marchand, Loic ;

Millastre, Esther ;

Andres, Raquel ;

Godino, Javier ;

Garcia-Prats, Maria Dolores ;

Polo, Eduardo ;

Tres, Alejandro ;

Mouy, Magali ;

Saemundsdottir, Jona ;

Backman, Valgerdur M. ;

Gudmundsson, Larus ;

Kristjansson, Kristleifur ;

Bergthorsson, Jon T. ;

Kostic, Jelena ;

Frigge, Michael L. ;

Geller, Frank ;

Gudbjartsson, Daniel ;

Sigurdsson, Helgi ;

Jonsdottir, Thora ;

Hrafnkelsson, Jon ;

Johannsson, Jakob ;

Sveinsson, Thorarinn ;

Myrdal, Gardar ;

Grimsson, Hlynur Niels ;

Jonsson, Thorvaldur ;

von Holst, Susanna ;

Werelius, Barbro ;

Margolin, Sara ;

Lindblom, Annika ;

Mayordomo, Jose I. ;

Haiman, Christopher A. ;

Kiemeney, Lambertus A. ;

Johannsson, Oskar Th ;

Gulcher, Jeffrey R. .

NATURE GENETICS, 2007, 39 (07) :865-869

[45] Two newly identified genetic determinants of pigmentation in Europeans [J].

Sulem, Patrick ;

Gudbjartsson, Daniel F. ;

Stacey, Simon N. ;

Helgason, Agnar ;

Rafnar, Thorunn ;

Jakobsdottir, Margret ;

Steinberg, Stacy ;

Gudjonsson, Sigurjon A. ;

Palsson, Arnar ;

Thorleifsson, Gudmar ;

Palsson, Snaebjoern ;

Sigurgeirsson, Bardur ;

Thorisdottir, Kristin ;

Ragnarsson, Rafn ;

Benediktsdottir, Kristrun R. ;

Aben, Katja K. ;

Vermeulen, Sita H. ;

Goldstein, Alisa M. ;

Tucker, Margaret A. ;

Kiemeney, Lambertus A. ;

Olafsson, Jon H. ;

Gulcher, Jeffrey ;

Kong, Augustine ;

Thorsteinsdottir, Unnur ;

Stefansson, Kari .

NATURE GENETICS, 2008, 40 (07) :835-837

[46] Genetic determinants of hair, eye and skin pigmentation in Europeans [J].

Sulem, Patrick ;

Gudbjartsson, Daniel F. ;

Stacey, Simon N. ;

Helgason, Agnar ;

Rafnar, Thorunn ;

Magnusson, Kristinn P. ;

Manolescu, Andrei ;

Karason, Ari ;

Palsson, Arnar ;

Thorleifsson, Gudmar ;

Jakobsdottir, Margret ;

Steinberg, Stacy ;

Palsson, Snaebjorn ;

Jonasson, Fridbert ;

Sigurgeirsson, Bardur ;

Thorisdottir, Kristin ;

Ragnarsson, Rafn ;

Benediktsdottir, Kristrun R. ;

Aben, Katja K. ;

Kiemeney, Lambertus A. ;

Olafsson, Jon H. ;

Gulcher, Jeffrey ;

Kong, Augie ;

Thorsteinsdottir, Unnur ;

Stefansson, Kari .

NATURE GENETICS, 2007, 39 (12) :1443-1452

[47] Evidence for two independent prostate cancer risk-associated loci in the HNF1B gene at 17q12 [J].

Sun, Jielin ;

Zheng, Siqun Lilly ;

Wiklund, Fredrik ;

Isaacs, Sarah D. ;

Purcell, Lina D. ;

Gao, Zhengrong ;

Hsu, Fang-Chi ;

Kim, Seong-Tae ;

Liu, Wennuan ;

Zhu, Yi ;

Stattin, Paer ;

Adami, Hans-Olov ;

Wiley, Kathleen E. ;

Dimitrov, Latchezar ;

Sun, Jishan ;

Li, Tao ;

Turner, Aubrey R. ;

Adams, Tamara S. ;

Adolfsson, Jan ;

Johansson, Jan-Erik ;

Lowey, James ;

Trock, Bruce J. ;

Partin, Alan W. ;

Walsh, Patrick C. ;

Trent, Jeffrey M. ;

Duggan, David ;

Carpten, John ;

Chang, Bao-Li ;

Gronberg, Henrik ;

Isaacs, William B. ;

Xu, Jianfeng .

NATURE GENETICS, 2008, 40 (10) :1153-1155

[48] Genome-wide association scan identifies a colorectal cancer susceptibility locus on 11q23 and replicates risk loci at 8q24 and 18q21 [J].

Tenesa, Albert ;

Farrington, Susan M. ;

Prendergast, James G. D. ;

Porteous, Mary E. ;

Walker, Marion ;

Haq, Naila ;

Barnetson, Rebecca A. ;

Theodoratou, Evropi ;

Cetnarskyj, Roseanne ;

Cartwright, Nicola ;

Semple, Colin ;

Clark, Andrew J. ;

Reid, Fiona J. L. ;

Smith, Lorna A. ;

Kavoussanakis, Kostas ;

Koessler, Thibaud ;

Pharoah, Paul D. P. ;

Buch, Stephan ;

Schafmayer, Clemens ;

Tepel, Juergen ;

Schreiber, Stefan ;

Voelzke, Henry ;

Schmidt, Carsten O. ;

Hampe, Jochen ;

Chang-Claude, Jenny ;

Hoffmeister, Michael ;

Brenner, Hermann ;

Wilkening, Stefan ;

Canzian, Federico ;

Capella, Gabriel ;

Moreno, Victor ;

Deary, Ian J. ;

Starr, John M. ;

Tomlinson, Ian P. M. ;

Kemp, Zoe ;

Howarth, Kimberley ;

Carvajal-Carmona, Luis ;

Webb, Emily ;

Broderick, Peter ;

Vijayakrishnan, Jayaram ;

Houlston, Richard S. ;

Rennert, Gad ;

Ballinger, Dennis ;

Rozek, Laura ;

Gruber, Stephen B. ;

Matsuda, Koichi ;

Kidokoro, Tomohide ;

Nakamura, Yusuke ;

Zanke, Brent W. ;

Greenwood, Celia M. T. .

NATURE GENETICS, 2008, 40 (05) :631-637

[49] Multiple loci identified in a genome-wide association study of prostate cancer [J].

Thomas, Gilles ;

Jacobs, Kevin B. ;

Yeager, Meredith ;

Kraft, Peter ;

Wacholder, Sholom ;

Orr, Nick ;

Yu, Kai ;

Chatterjee, Nilanjan ;

Welch, Robert ;

Hutchinson, Amy ;

Crenshaw, Andrew ;

Cancel-Tassin, Geraldine ;

Staats, Brian J. ;

Wang, Zhaoming ;

Gonzalez-Bosquet, Jesus ;

Fang, Jun ;

Deng, Xiang ;

Berndt, Sonja I. ;

Calle, Eugenia E. ;

Feigelson, Heather Spencer ;

Thun, Michael J. ;

Rodriguez, Carmen ;

Albanes, Demetrius ;

Virtamo, Jarmo ;

Weinstein, Stephanie ;

Schumacher, Fredrick R. ;

Giovannucci, Edward ;

Willett, Walter C. ;

Cussenot, Olivier ;

Valeri, Antoine ;

Andriole, Gerald L. ;

Crawford, E. David ;

Tucker, Margaret ;

Gerhard, Daniela S. ;

Fraumeni, Joseph F., Jr. ;

Hoover, Robert ;

Hayes, Richard B. ;

Hunter, David J. ;

Chanock, Stephen J. .

NATURE GENETICS, 2008, 40 (03) :310-315

[50] Cancer risks and mortality in heterozygous ATM mutation carriers [J].

Thompson, D ;

Duedal, S ;

Kirner, JFR ;

McGuffog, L ;

Last, J ;

Reiman, A ;

Byrd, P ;

Taylor, M ;

Easton, DF .

JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE, 2005, 97 (11) :813-822

← 1 2 3 4 5 6 →

共 58 条

[41] ATM mutations that cause ataxia-telangiectasia are breast cancer susceptibility alleles [J].

Renwick, Anthony ;

Thompson, Deborah ;

Seal, Sheila ;

Kelly, Patrick ;

Chagtai, Tasnim ;

Ahmed, Munaza ;

North, Bernard ;

Jayatilake, Hiran ;

Barfoot, Rita ;

Spanova, Katarina ;

McGuffog, Lesley ;

Evans, D. Gareth ;

Eccles, Diana ;

Easton, Douglas F. ;

Stratton, Michael R. ;

Rahman, Nazneen .

NATURE GENETICS, 2006, 38 (08) :873-875

[42] Truncating mutations in the Fanconi anemia J gene BRIP1 are low-penetrance breast cancer susceptibility alleles [J].

Seal, Sheila ;

Thompson, Deborah ;

Renwick, Anthony ;

Elliott, Anna ;

Kelly, Patrick ;

Barfoot, Rita ;

Chagtai, Tasnim ;

Jayatilake, Hiran ;

Ahmed, Munaza ;

Spanova, Katarina ;

North, Bernard ;

McGuffog, Lesley ;

Evans, D. Gareth ;

Eccles, Diana ;

Easton, Douglas F. ;

Stratton, Michael R. ;

Rahman, Nazneen .

NATURE GENETICS, 2006, 38 (11) :1239-1241

[43] Common variants on chromosome 5p12 confer susceptibility to estrogen receptor-positive breast cancer [J].

Stacey, Simon N. ;

Manolescu, Andrei ;

Sulem, Patrick ;

Thorlacius, Steinunn ;

Gudjonsson, Sigurjon A. ;

Jonsson, Gudbjorn F. ;

Jakobsdottir, Margret ;

Bergthorsson, Jon T. ;

Gudmundsson, Julius ;

Aben, Katja K. ;

Strobbe, Luc J. ;

Swinkels, Dorine W. ;

van Engelenburg, K. C. Anton ;

Henderson, Brian E. ;

Kolonel, Laurence N. ;

Le Marchand, Loic ;

Millastre, Esther ;

Andres, Raquel ;

Saez, Berta ;

Lambea, Julio ;

Godino, Javier ;

Polo, Eduardo ;

Tres, Alejandro ;

Picelli, Simone ;

Rantala, Johanna ;

Margolin, Sara ;

Jonsson, Thorvaldur ;

Sigurdsson, Helgi ;

Jonsdottir, Thora ;

Hrafnkelsson, Jon ;

Johannsson, Jakob ;

Sveinsson, Thorarinn ;

Myrdal, Gardar ;

Grimsson, Hlynur Niels ;

Sveinsdottir, Steinunn G. ;

Alexiusdottir, Kristin ;

Saemundsdottir, Jona ;

Sigurdsson, Asgeir ;

Kostic, Jelena ;

Gudmundsson, Larus ;

Kristjansson, Kristleifur ;

Masson, Gisli ;

Fackenthal, James D. ;

Adebamowo, Clement ;

Ogundiran, Temidayo ;

Olopade, Olufunmilayo I. ;

Haiman, Christopher A. ;

Lindblom, Annika ;

Mayordomo, Jose I. ;

Kiemeney, Lambertus A. .

NATURE GENETICS, 2008, 40 (06) :703-706

[44] Common variants on chromosomes 2q35 and 16q12 confer susceptibility to estrogen receptor-positive breast cancer [J].

Stacey, Simon N. ;

Manolescu, Andrei ;

Sulem, Patrick ;

Rafnar, Thorunn ;

Gudmundsson, Julius ;

Gudjonsson, Sigurjon A. ;

Masson, Gisli ;

Jakobsdottir, Margret ;

Thorlacius, Steinunn ;

Helgason, Agnar ;

Aben, Katja K. ;

Strobbe, Luc J. ;

Albers-Akkers, Marjo T. ;

Swinkels, Dorine W. ;

Henderson, Brian E. ;

Kolonel, Laurence N. ;

Le Marchand, Loic ;

Millastre, Esther ;

Andres, Raquel ;

Godino, Javier ;

Garcia-Prats, Maria Dolores ;

Polo, Eduardo ;

Tres, Alejandro ;

Mouy, Magali ;

Saemundsdottir, Jona ;

Backman, Valgerdur M. ;

Gudmundsson, Larus ;

Kristjansson, Kristleifur ;

Bergthorsson, Jon T. ;

Kostic, Jelena ;

Frigge, Michael L. ;

Geller, Frank ;

Gudbjartsson, Daniel ;

Sigurdsson, Helgi ;

Jonsdottir, Thora ;

Hrafnkelsson, Jon ;

Johannsson, Jakob ;

Sveinsson, Thorarinn ;

Myrdal, Gardar ;

Grimsson, Hlynur Niels ;

Jonsson, Thorvaldur ;

von Holst, Susanna ;

Werelius, Barbro ;

Margolin, Sara ;

Lindblom, Annika ;

Mayordomo, Jose I. ;

Haiman, Christopher A. ;

Kiemeney, Lambertus A. ;

Johannsson, Oskar Th ;

Gulcher, Jeffrey R. .

NATURE GENETICS, 2007, 39 (07) :865-869

[45] Two newly identified genetic determinants of pigmentation in Europeans [J].

Sulem, Patrick ;

Gudbjartsson, Daniel F. ;

Stacey, Simon N. ;

Helgason, Agnar ;

Rafnar, Thorunn ;

Jakobsdottir, Margret ;

Steinberg, Stacy ;

Gudjonsson, Sigurjon A. ;

Palsson, Arnar ;

Thorleifsson, Gudmar ;

Palsson, Snaebjoern ;

Sigurgeirsson, Bardur ;

Thorisdottir, Kristin ;

Ragnarsson, Rafn ;

Benediktsdottir, Kristrun R. ;

Aben, Katja K. ;

Vermeulen, Sita H. ;

Goldstein, Alisa M. ;

Tucker, Margaret A. ;

Kiemeney, Lambertus A. ;

Olafsson, Jon H. ;

Gulcher, Jeffrey ;

Kong, Augustine ;

Thorsteinsdottir, Unnur ;

Stefansson, Kari .

NATURE GENETICS, 2008, 40 (07) :835-837

[46] Genetic determinants of hair, eye and skin pigmentation in Europeans [J].

Sulem, Patrick ;

Gudbjartsson, Daniel F. ;

Stacey, Simon N. ;

Helgason, Agnar ;

Rafnar, Thorunn ;

Magnusson, Kristinn P. ;

Manolescu, Andrei ;

Karason, Ari ;

Palsson, Arnar ;

Thorleifsson, Gudmar ;

Jakobsdottir, Margret ;

Steinberg, Stacy ;

Palsson, Snaebjorn ;

Jonasson, Fridbert ;

Sigurgeirsson, Bardur ;

Thorisdottir, Kristin ;

Ragnarsson, Rafn ;

Benediktsdottir, Kristrun R. ;

Aben, Katja K. ;

Kiemeney, Lambertus A. ;

Olafsson, Jon H. ;

Gulcher, Jeffrey ;

Kong, Augie ;

Thorsteinsdottir, Unnur ;

Stefansson, Kari .

NATURE GENETICS, 2007, 39 (12) :1443-1452

[47] Evidence for two independent prostate cancer risk-associated loci in the HNF1B gene at 17q12 [J].

Sun, Jielin ;

Zheng, Siqun Lilly ;

Wiklund, Fredrik ;

Isaacs, Sarah D. ;

Purcell, Lina D. ;

Gao, Zhengrong ;

Hsu, Fang-Chi ;

Kim, Seong-Tae ;

Liu, Wennuan ;

Zhu, Yi ;

Stattin, Paer ;

Adami, Hans-Olov ;

Wiley, Kathleen E. ;

Dimitrov, Latchezar ;

Sun, Jishan ;

Li, Tao ;

Turner, Aubrey R. ;

Adams, Tamara S. ;

Adolfsson, Jan ;

Johansson, Jan-Erik ;

Lowey, James ;

Trock, Bruce J. ;

Partin, Alan W. ;

Walsh, Patrick C. ;

Trent, Jeffrey M. ;

Duggan, David ;

Carpten, John ;

Chang, Bao-Li ;

Gronberg, Henrik ;

Isaacs, William B. ;

Xu, Jianfeng .

NATURE GENETICS, 2008, 40 (10) :1153-1155

[48] Genome-wide association scan identifies a colorectal cancer susceptibility locus on 11q23 and replicates risk loci at 8q24 and 18q21 [J].

Tenesa, Albert ;

Farrington, Susan M. ;

Prendergast, James G. D. ;

Porteous, Mary E. ;

Walker, Marion ;

Haq, Naila ;

Barnetson, Rebecca A. ;

Theodoratou, Evropi ;

Cetnarskyj, Roseanne ;

Cartwright, Nicola ;

Semple, Colin ;

Clark, Andrew J. ;

Reid, Fiona J. L. ;

Smith, Lorna A. ;

Kavoussanakis, Kostas ;

Koessler, Thibaud ;

Pharoah, Paul D. P. ;

Buch, Stephan ;

Schafmayer, Clemens ;

Tepel, Juergen ;

Schreiber, Stefan ;

Voelzke, Henry ;

Schmidt, Carsten O. ;

Hampe, Jochen ;

Chang-Claude, Jenny ;

Hoffmeister, Michael ;

Brenner, Hermann ;

Wilkening, Stefan ;

Canzian, Federico ;

Capella, Gabriel ;

Moreno, Victor ;

Deary, Ian J. ;

Starr, John M. ;

Tomlinson, Ian P. M. ;

Kemp, Zoe ;

Howarth, Kimberley ;

Carvajal-Carmona, Luis ;

Webb, Emily ;

Broderick, Peter ;

Vijayakrishnan, Jayaram ;

Houlston, Richard S. ;

Rennert, Gad ;

Ballinger, Dennis ;

Rozek, Laura ;

Gruber, Stephen B. ;

Matsuda, Koichi ;

Kidokoro, Tomohide ;

Nakamura, Yusuke ;

Zanke, Brent W. ;

Greenwood, Celia M. T. .

NATURE GENETICS, 2008, 40 (05) :631-637

[49] Multiple loci identified in a genome-wide association study of prostate cancer [J].

Thomas, Gilles ;

Jacobs, Kevin B. ;

Yeager, Meredith ;

Kraft, Peter ;

Wacholder, Sholom ;

Orr, Nick ;

Yu, Kai ;

Chatterjee, Nilanjan ;

Welch, Robert ;

Hutchinson, Amy ;

Crenshaw, Andrew ;

Cancel-Tassin, Geraldine ;

Staats, Brian J. ;

Wang, Zhaoming ;

Gonzalez-Bosquet, Jesus ;

Fang, Jun ;

Deng, Xiang ;

Berndt, Sonja I. ;

Calle, Eugenia E. ;

Feigelson, Heather Spencer ;

Thun, Michael J. ;

Rodriguez, Carmen ;

Albanes, Demetrius ;

Virtamo, Jarmo ;

Weinstein, Stephanie ;

Schumacher, Fredrick R. ;

Giovannucci, Edward ;

Willett, Walter C. ;

Cussenot, Olivier ;

Valeri, Antoine ;

Andriole, Gerald L. ;

Crawford, E. David ;

Tucker, Margaret ;

Gerhard, Daniela S. ;

Fraumeni, Joseph F., Jr. ;

Hoover, Robert ;

Hayes, Richard B. ;

Hunter, David J. ;

Chanock, Stephen J. .

NATURE GENETICS, 2008, 40 (03) :310-315

[50] Cancer risks and mortality in heterozygous ATM mutation carriers [J].

Thompson, D ;

Duedal, S ;

Kirner, JFR ;

McGuffog, L ;

Last, J ;

Reiman, A ;

Byrd, P ;

Taylor, M ;

Easton, DF .

JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE, 2005, 97 (11) :813-822

← 1 2 3 4 5 6 →