Chemo-enzymatic synthesis of chiral 2-substituted succinic acid derivatives

被引：7

作者：

Bailey, MD ^{[1
]}

Halmos, T ^{[1
]}

Adamson, D ^{[1
]}

Bordeleau, J ^{[1
]}

Grand-Maître, C ^{[1
]}

机构：

[1] Boehringer Ingelheim Canada Ltd, BioMega Res Div, Laval, PQ H7S 2G5, Canada

来源：

TETRAHEDRON-ASYMMETRY | 1999年 / 10卷 / 17期

关键词：

D O I：

10.1016/S0957-4166(99)00330-4

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

Prochiral discrimination by the biocatalyst Alcalase(R), an enzyme preparation of subtilisin Carlsberg, was used to effect enantio- and regioselective monohydrolysis of a variety of(RS)-2-substituted succinate diesters to afford the corresponding half esters in modest to excellent enantiomeric excesses (>99%). Exploitation of malonate chemistry, as well as recycling of the unhydrolyzed isomer from the enantioselective hydrolysis, has resulted in a process which is both practical and economical. (C) 1999 Published by Elsevier Science Ltd. All rights reserved.

引用

页码：3285 / 3295

页数：11

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