PTEN function in mammalian cell size regulation

被引：77

作者：

Backman, SA

Stambolic, V

Mak, TW

机构：

[1] Univ Toronto, Dept Med Biophys, Toronto, ON M5G 2M9, Canada

[2] Ontario Canc Inst, Toronto, ON M5G 2M9, Canada

来源：

CURRENT OPINION IN NEUROBIOLOGY | 2002年 / 12卷 / 05期

关键词：

D O I：

10.1016/S0959-4388(02)00354-9

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The PTEN tumor suppressor gene is a lipid phosphatase that negatively regulates cell survival mediated by the phosphatidyl inositol 3'kinase-protein kinase B/Akt signaling pathway. Recent in vivo studies have revealed a novel role for PTEN in the size control of neurons. Dysregulation of cell growth control by PTEN is associated with the neurological disorder Lhermitte-Duclos disease. PTEN may regulate cell size through effects on protein translation.

引用

页码：516 / 522

页数：7

共 69 条

[31] Crystal structure of the PTEN tumor suppressor: Implications for its phosphoinositide phosphatase activity and membrane association
Lee, JO
Yang, HJ
Georgescu, MM
Di Cristofano, A
Maehama, T
Shi, YG
Dixon, JE
Pandolfi, P
Pavletich, NP
[J]. CELL, 1999, 99 (03) : 323 - 334
[32] Li DM, 1997, CANCER RES, V57, P2124
[33] PTEN/MMAC1/TEP1 suppresses the tumorigenicity and induces G1 cell cycle arrest in human glioblastoma cells
Li, DM
Sun, H
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1998, 95 (26) : 15406 - 15411
[34] PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancer
Li, J
Yen, C
Liaw, D
Podsypanina, K
Bose, S
Wang, SI
Puc, J
Miliaresis, C
Rodgers, L
McCombie, R
Bigner, SH
Giovanella, BC
Ittmann, M
Tycko, B
Hibshoosh, H
Wigler, MH
Parsons, R
[J]. SCIENCE, 1997, 275 (5308) : 1943 - 1947
[35] The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-trisphosphate
Maehama, T
Dixon, JE
[J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 1998, 273 (22) : 13375 - 13378
[36] The translational inhibitor 4E-BP is an effector of PI(3)K/Akt signalling and cell growth in Drosophila
Miron, M
Verdú, J
Lachance, PED
Birnbaum, MJ
Lasko, PF
Sonenberg, N
[J]. NATURE CELL BIOLOGY, 2001, 3 (06) : 596 - 601
[37] Drosophila S6 kinase: A regulator of cell size
Montagne, J
Stewart, MJ
Stocker, H
Hafen, E
Kozma, SC
Thomas, G
[J]. SCIENCE, 1999, 285 (5436) : 2126 - 2129
[38] Genetic and biochemical characterization of dTOR, the Drosophila homolog of the target of rapamycin
Oldham, S
Montagne, J
Radimerski, T
Thomas, G
Hafen, E
[J]. GENES & DEVELOPMENT, 2000, 14 (21) : 2689 - 2694
[39] EPIDERMAL NEVUS SYNDROME - A NEUROLOGIC VARIANT WITH HEMIMEGALENCEPHALY, GYRAL MALFORMATION, MENTAL-RETARDATION, SEIZURES, AND FACIAL HEMIHYPERTROPHY
PAVONE, L
CURATOLO, P
RIZZO, R
MICALI, G
INCORPORA, G
GARG, BP
DUNN, DW
DOBYNS, WB
[J]. NEUROLOGY, 1991, 41 (02) : 266 - 271
[40] Hypoinsulinaemia, glucose intolerance and diminished β-cell size in S6K1-deficient mice
Pende, M
Kozma, SC
Jaquet, M
Oorschot, V
Burcelin, R
Le Marchand-Brustel, Y
Klumperman, J
Thorens, B
Thomas, G
[J]. NATURE, 2000, 408 (6815) : 994 - 997

← 1 2 3 4 5 6 7 →