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PTEN function in mammalian cell size regulation

被引：77
作者：
Backman, SA
Stambolic, V
Mak, TW
机构：
[1] Univ Toronto, Dept Med Biophys, Toronto, ON M5G 2M9, Canada
[2] Ontario Canc Inst, Toronto, ON M5G 2M9, Canada
来源：
CURRENT OPINION IN NEUROBIOLOGY | 2002年 / 12卷 / 05期
关键词：
D O I：
10.1016/S0959-4388(02)00354-9
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
The PTEN tumor suppressor gene is a lipid phosphatase that negatively regulates cell survival mediated by the phosphatidyl inositol 3'kinase-protein kinase B/Akt signaling pathway. Recent in vivo studies have revealed a novel role for PTEN in the size control of neurons. Dysregulation of cell growth control by PTEN is associated with the neurological disorder Lhermitte-Duclos disease. PTEN may regulate cell size through effects on protein translation.
引用
收藏
页码：516 / 522
页数：7
相关论文
共 69 条
  • [51] Modulation of cellular apoptotic potential: contributions to oncogenesis
    Stambolic, V
    Mak, TW
    Woodgett, JR
    [J]. ONCOGENE, 1999, 18 (45) : 6094 - 6103
  • [52] Negative regulation of PKB/Akt-dependent cell survival by the tumor suppressor PTEN
    Stambolic, V
    Suzuki, A
    de la Pompa, JL
    Brothers, GM
    Mirtsos, C
    Sasaki, T
    Ruland, J
    Penninger, JM
    Siderovski, DP
    Mak, TW
    [J]. CELL, 1998, 95 (01) : 29 - 39
  • [53] Identification of a candidate tumour suppressor gene, MMAC1, at chromosome 10q23.3 that is mutated in multiple advanced cancers
    Steck, PA
    Pershouse, MA
    Jasser, SA
    Yung, WKA
    Lin, H
    Ligon, AH
    Langford, LA
    Baumgard, ML
    Hattier, T
    Davis, T
    Frye, C
    Hu, R
    Swedlund, B
    Teng, DHF
    Tavtigian, SV
    [J]. NATURE GENETICS, 1997, 15 (04) : 356 - 362
  • [54] Genetic control of cell size
    Stocker, H
    Hafen, E
    [J]. CURRENT OPINION IN GENETICS & DEVELOPMENT, 2000, 10 (05) : 529 - 535
  • [55] Living with lethal PIP3 levels: Viability of flies lacking PTEN restored by a PH domain mutation in Akt/PKB
    Stocker, H
    Andjelkovic, M
    Oldham, S
    Laffargue, M
    Wymann, MP
    Hemmings, BA
    Hafen, E
    [J]. SCIENCE, 2002, 295 (5562) : 2088 - 2091
  • [56] PTEN modulates cell cycle progression and cell survival by regulating phosphatidylinositol 3,4,5,-trisphosphate and Akt protein kinase B signaling pathway
    Sun, H
    Lesche, R
    Li, DM
    Liliental, J
    Zhang, H
    Gao, J
    Gavrilova, N
    Mueller, B
    Liu, X
    Wu, H
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1999, 96 (11) : 6199 - 6204
  • [57] Sutphen R, 1999, AM J MED GENET, V82, P290, DOI 10.1002/(SICI)1096-8628(19990212)82:4<290::AID-AJMG3>3.0.CO
  • [58] 2-0
  • [59] The Drosophila tuberous sclerosis complex gene homologs restrict cell growth and cell proliferation
    Tapon, N
    Ito, N
    Dickson, BJ
    Treisman, JE
    Hariharan, IK
    [J]. CELL, 2001, 105 (03) : 345 - 355
  • [60] c-Myc regulates mammalian body size by controlling cell number but not cell size
    Trumpp, A
    Refaeli, Y
    Oskarsson, T
    Gasser, S
    Murphy, M
    Martin, GR
    Bishop, JM
    [J]. NATURE, 2001, 414 (6865) : 768 - 773
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