Plasma concentrations and role of macrophage inflammatory protein-1α during chronic Schistosoma mansoni infection in humans

被引:34
作者
Falcao, PL
Correa-Oliveira, R
Fraga, LAO
Talvani, A
Proudfoot, AEI
Wells, TNC
Williams, TJ
Jose, PJ
Teixeira, MM
机构
[1] Univ Fed Minas Gerais, Inst Ciencias Biol, Dept Bioquim & Imunol, BR-31270901 Belo Horizonte, MG, Brazil
[2] Fundacao Oswaldo Cruz, Ctr Pesquisas Rene Rachou, Belo Horizonte, MG, Brazil
[3] Univ Vale Rio Doce, Governador Valadares, Brazil
[4] Serono Pharmaceut, Geneva, Switzerland
[5] Univ London Imperial Coll Sci Technol & Med, Fac Med, London, England
关键词
D O I
10.1086/345370
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Chemokines play an important role during granulomatous inflammation in murine models of Schistosoma mansoni infection. Here, the expression and possible roles of chemokines during human S. mansoni infection were examined. Compared with uninfected individuals, infected patients had elevated plasma concentrations of macrophage inflammatory protein (MIP)-1alpha, RANTES (regulated on activation, normally T cell-expressed and secreted), and eotaxin. Concentrations of macrophage-derived chemokine, eotaxin-2, monocyte chemotactic protein-1, growth-related oncogene, and interleukin-8 were similar between the 2 groups. When subjects were grouped according to disease severity, individuals with a plasma MIP-1 concentration >400 pM had a 10-times greater risk of having the more severe hepatosplenic form of disease. In the in vitro granuloma reaction, greater concentrations of MIP-1alpha were produced by cells of patients with hepatosplenic disease than cells of patients with intestinal disease. Pretreatment with a chemokine receptor antagonist attenuated the enhanced in vitro reaction seen with cells derived from patients with hepatosplenic disease. MIP-1alpha may not only mark a subset of patients with a greater risk of having more severe disease but also play a relevant pathophysiological role in human schistosomiasis.
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收藏
页码:1696 / 1700
页数:5
相关论文
共 13 条
[1]   Molecular machinations: Chemokine signals in host-pathogen interactions [J].
Chensue, SW .
CLINICAL MICROBIOLOGY REVIEWS, 2001, 14 (04) :821-835
[2]  
DOUGHTY BL, 1984, J IMMUNOL, V133, P993
[3]  
Falcao PL, 1998, PARASITE IMMUNOL, V20, P447, DOI 10.1046/j.1365-3024.1998.00166.x
[4]   Immunopathology of schistosomiasis: a cautionary tale of mice and men [J].
Fallon, PG .
IMMUNOLOGY TODAY, 2000, 21 (01) :29-35
[5]   Chemokines and disease [J].
Gerard, C ;
Rollins, BJ .
NATURE IMMUNOLOGY, 2001, 2 (02) :108-115
[6]   THE ROLE OF MACROPHAGE INFLAMMATORY PROTEIN-1-ALPHA IN SCHISTOSOMA-MANSONI EGG-INDUCED GRANULOMATOUS INFLAMMATION [J].
LUKACS, NW ;
KUNKEL, SL ;
STRIETER, RM ;
WARMINGTON, K ;
CHENSUE, SW .
JOURNAL OF EXPERIMENTAL MEDICINE, 1993, 177 (06) :1551-1559
[7]   Chemokines: immunology's high impact factors [J].
Mackay, CR .
NATURE IMMUNOLOGY, 2001, 2 (02) :95-101
[8]  
Mwatha JK, 1998, J IMMUNOL, V160, P1992
[9]  
Neves J, 1965, Rev Inst Med Trop Sao Paulo, V7, P256
[10]   Nitric oxide interaction with IL-10, MIP-1α, MCP-1 and RANTES over the in vitro granuloma formation against different Schistosoma mansoni antigenic preparations on human schistosomiasis [J].
Oliveira, DM ;
Silva-Teixeira, DN ;
Gustavson, S ;
Oliveira, SMP ;
Goes, AM .
PARASITOLOGY, 2000, 120 :391-398