Accelerating drug discovery by integrative implementation of laboratory automation in the work flow

被引：18

作者：

Nettekoven, M ^{[1
]}

Thomas, AW ^{[1
]}

机构：

[1] F Hoffmann LaRoche Ltd, Pharmaceut Res Basel, Discovery Chem, CH-4070 Basel, Switzerland

来源：

CURRENT MEDICINAL CHEMISTRY | 2002年 / 9卷 / 23期

关键词：

drug discovery; combinatorial chemistry; parallel synthesis; laboratory automation; integrative workflow concept; case studies;

D O I：

10.2174/0929867023368764

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Acceleration of the drug discovery process in pre-clinical pharmaceutical research is a highly desirable goal and combinatorial chemistry united with automation technology promised to accomplish this task. Through the accumulation of experience with automated devices over time it became evident that only by harmonisation and streamlining of work-flow procedures the efficiency of the overall process can be improved. An open architecture of efficient data management and appropriate utilisation of automated laboratory protocols provides the opportunity to react in a flexible and advisable way. Only an integrative workflow concept promotes the enhancement of the overall performance. However, the foundation of any efforts towards the accelerated synthesis of new and desired compound arrays lies in the development of reliable chemistry protocols amenable to solid- and solution phase chemistry.

引用

页码：2179 / 2190

页数：12

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