The Genetics of Alzheimer's Disease

被引:155
作者
Bertram, Lars [1 ]
Tanzi, Rudolph E. [2 ]
机构
[1] Max Planck Inst Mol Genet, Dept Vertebrate Genom, D-14195 Berlin, Germany
[2] Harvard Univ, Massachusetts Gen Hosp, Sch Med, Genet & Aging Res Unit, Boston, MA USA
来源
MOLECULAR BIOLOGY OF NEURODEGENERATIVE DISEASES | 2012年 / 107卷
关键词
GENOME-WIDE ASSOCIATION; AMYLOID BETA-PROTEIN; DENSITY-LIPOPROTEIN RECEPTOR; PRECURSOR PROTEIN; SUSCEPTIBILITY GENES; IDENTIFIES VARIANTS; MISSENSE MUTATIONS; RARE VARIANTS; RISK-FACTOR; A-BETA;
D O I
10.1016/B978-0-12-385883-2.00008-4
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
070307 [化学生物学]; 071010 [生物化学与分子生物学];
摘要
引用
收藏
页码:79 / 100
页数:22
相关论文
共 89 条
[31]
Presenilin-dependent processing and nuclear function of γ-protocadherins [J].
Haas, IG ;
Frank, M ;
Véron, N ;
Kemler, R .
JOURNAL OF BIOLOGICAL CHEMISTRY, 2005, 280 (10) :9313-9319
[32]
Evidence for CALM in directing VAMP2 trafficking [J].
Harel, Asaff ;
Wu, Fangbai ;
Mattson, Mark P. ;
Morris, Christa M. ;
Yao, Pamela J. .
TRAFFIC, 2008, 9 (03) :417-429
[33]
Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease [J].
Harold, Denise ;
Abraham, Richard ;
Hollingworth, Paul ;
Sims, Rebecca ;
Gerrish, Amy ;
Hamshere, Marian L. ;
Pahwa, Jaspreet Singh ;
Moskvina, Valentina ;
Dowzell, Kimberley ;
Williams, Amy ;
Jones, Nicola ;
Thomas, Charlene ;
Stretton, Alexandra ;
Morgan, Angharad R. ;
Lovestone, Simon ;
Powell, John ;
Proitsi, Petroula ;
Lupton, Michelle K. ;
Brayne, Carol ;
Rubinsztein, David C. ;
Gill, Michael ;
Lawlor, Brian ;
Lynch, Aoibhinn ;
Morgan, Kevin ;
Brown, Kristelle S. ;
Passmore, Peter A. ;
Craig, David ;
McGuinness, Bernadette ;
Todd, Stephen ;
Holmes, Clive ;
Mann, David ;
Smith, A. David ;
Love, Seth ;
Kehoe, Patrick G. ;
Hardy, John ;
Mead, Simon ;
Fox, Nick ;
Rossor, Martin ;
Collinge, John ;
Maier, Wolfgang ;
Jessen, Frank ;
Schuermann, Britta ;
van den Bussche, Hendrik ;
Heuser, Isabella ;
Kornhuber, Johannes ;
Wiltfang, Jens ;
Dichgans, Martin ;
Froelich, Lutz ;
Hampel, Harald ;
Huell, Michael .
NATURE GENETICS, 2009, 41 (10) :1088-U61
[34]
Genome-Wide Scan of Copy Number Variation in Late-Onset Alzheimer's Disease [J].
Heinzen, Erin L. ;
Need, Anna C. ;
Hayden, Kathleen M. ;
Chiba-Falek, Ornit ;
Roses, Allen D. ;
Strittmatter, Warren J. ;
Burke, James R. ;
Hulette, Christine M. ;
Welsh-Bohmer, Kathleen A. ;
Goldstein, David B. .
JOURNAL OF ALZHEIMERS DISEASE, 2010, 19 (01) :69-77
[35]
Amyloid β-protein is degraded by cellular angiotensin-converting enzyme (ACE) and elevated by an ACE inhibitor [J].
Hemming, ML ;
Selkoe, DJ .
JOURNAL OF BIOLOGICAL CHEMISTRY, 2005, 280 (45) :37644-37650
[36]
Angiotensin-converting enzyme degrades Alzheimer amyloid β-peptide (Aβ);: Retards Aβ aggregation, deposition, fibril formation, and inhibits cytotoxicity. [J].
Hu, JG ;
Igarashi, A ;
Kamata, M ;
Nakagawa, H .
JOURNAL OF BIOLOGICAL CHEMISTRY, 2001, 276 (51) :47863-47868
[37]
Excess of rare variants in genes identified by genome-wide association study of hypertriglyceridemia [J].
Johansen, Christopher T. ;
Wang, Jian ;
Lanktree, Matthew B. ;
Cao, Henian ;
McIntyre, Adam D. ;
Ban, Matthew R. ;
Martins, Rebecca A. ;
Kennedy, Brooke A. ;
Hassell, Reina G. ;
Visser, Maartje E. ;
Schwartz, Stephen M. ;
Voight, Benjamin F. ;
Elosua, Roberto ;
Salomaa, Veikko ;
O'Donnell, Christopher J. ;
Dallinga-Thie, Geesje M. ;
Anand, Sonia S. ;
Yusuf, Salim ;
Huff, Murray W. ;
Kathiresan, Sekar ;
Hegele, Robert A. .
NATURE GENETICS, 2010, 42 (08) :684-+
[38]
Cystatin C modulates cerebral β-amyloidosis [J].
Kaeser, Stephan A. ;
Herzig, Martin C. ;
Coomaraswamy, Janaky ;
Kilger, Ellen ;
Selenica, Maj-Linda ;
Winkler, David T. ;
Staufenbiel, Matthias ;
Levy, Efrat ;
Grubb, Anders ;
Jucker, Mathias .
NATURE GENETICS, 2007, 39 (12) :1437-1439
[39]
Variation in DCP1, encoding ACE, is associated with susceptibility to Alzheimer disease [J].
Kehoe, PG ;
Russ, C ;
McIlroy, S ;
Williams, H ;
Holmans, P ;
Holmes, C ;
Liolitsa, D ;
Vahidassr, D ;
Powell, J ;
McGleenon, B ;
Liddell, M ;
Plomin, R ;
Dynan, K ;
Williams, N ;
Neal, J ;
Cairns, NJ ;
Wilcock, G ;
Passmore, P ;
Lovestone, S ;
Williams, J ;
Owen, MJ .
NATURE GENETICS, 1999, 21 (01) :71-72
[40]
Complement Receptor 1: Disease associations and therapeutic implications [J].
Khera, Rohan ;
Das, Nibhriti .
MOLECULAR IMMUNOLOGY, 2009, 46 (05) :761-772