Cystatin C modulates cerebral β-amyloidosis

被引：158

作者：

Kaeser, Stephan A.

Herzig, Martin C.

Coomaraswamy, Janaky

Kilger, Ellen

Selenica, Maj-Linda

Winkler, David T.

Staufenbiel, Matthias

Levy, Efrat

Grubb, Anders

Jucker, Mathias

机构：

[1] Univ Tubingen, Hertie Inst Clin Brain Res, Dept Cellular Neurol, D-72076 Tubingen, Germany

[2] Univ Lund Hosp, Dept Clin Chem, S-22185 Lund, Sweden

[3] Univ Basel, Inst Pathol, Dept Neuropathol, CH-4003 Basel, Switzerland

[4] Novartis Inst Biomed Res Basel, CH-4002 Basel, Switzerland

[5] NYU, Sch Med, Dept Pharmacol & Psychiat, New York, NY 10016 USA

[6] Nathan S Kline Inst, New York, NY 10962 USA

来源：

NATURE GENETICS | 2007年 / 39卷 / 12期

关键词：

D O I：

10.1038/ng.2007.23

中图分类号：

Q3 [遗传学];

学科分类号：

071007 [遗传学]; 090102 [作物遗传育种];

摘要：

The CST3 Thr25 allele of CST3, which encodes cystatin C, leads to reduced cystatin C secretion and conveys susceptibility to Alzheimer's disease. Here we show that overexpression of human cystatin C in brains of APP-transgenic mice reduces cerebral amyloid-beta deposition and that cystatin C binds amyloid-beta and inhibits its fibril formation. Our results suggest that cystatin C concentrations modulate cerebral amyloidosis risk and provide an opportunity for genetic risk assessment and therapeutic interventions.

引用

页码：1437 / 1439

页数：3

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