Reconstructed Stem Cell Nanoghosts: A Natural Tumor Targeting Platform

被引：263

作者：

Furman, Naama E. Toledano ^{[1
]}

Lupu-Haber, Yael ^{[1
]}

Bronshtein, Tomer ^{[1
]}

Kaneti, Limor ^{[1
]}

Letko, Nitzan ^{[1
]}

Weinstein, Eyal ^{[1
]}

Baruch, Limor ^{[1
]}

Machluf, Marcelle ^{[1
]}

机构：

[1] Technion Israel Inst Technol, Fac Biotechnol & Food Engn, IL-32000 Haifa, Israel

来源：

NANO LETTERS | 2013年 / 13卷 / 07期

关键词：

Nanoghosts; drug delivery; mesenchymal stem cells; cancer targeted therapy; DRUG-DELIVERY; S-TRAIL; CANCER; NANOPARTICLES; LIPOSOMES; SYSTEMS; GLIOMA;

D O I：

10.1021/nl401376w

中图分类号：

O6 [化学];

学科分类号：

070301 [无机化学];

摘要：

The ultimate goal in cancer therapy is achieving selective targeting of cancer cells. We report a novel delivery platform, based on nanoghosts (NGs) produced from the membranes of mesenchymal stem cells (MSCs). Encompassing MSC surface molecules, the MSC-NGs retained MSC-specific in vitro and in vivo tumor targeting capabilities and were cleared from blood-filtering organs. MSC-NGs were found to be biocompatible. Systemic administration of drug loaded MSC-NGs demonstrated 80% inhibition of human prostate cancer.

引用

页码：3248 / 3255

页数：8

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