Formation and function of the lytic NK-cell immunological synapse

被引：444

作者：

Orange, Jordan S. ^{[1
]}

机构：

[1] Univ Penn, Sch Med, Childrens Hosp Philadelphia, Joseph Stokes Jr Res Inst, Philadelphia, PA 19104 USA

来源：

NATURE REVIEWS IMMUNOLOGY | 2008年 / 8卷 / 09期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1038/nri2381

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The natural killer (NK)-cell immunological synapse is the dynamic interface formed between an NK cell and its target cell. Formation of the NK-cell immunological synapse involves several distinct stages, from the initiation of contact with a target cell to the directed delivery of lytic-granule contents for target-cell lysis. Progression through the individual stages is regulated, and this tight regulation underlies the precision with which NK cells select and kill susceptible target cells (including virally infected cells and cancerous cells) that they encounter during their routine surveillance of the body.

引用

页码：713 / 725

页数：13

共 141 条

[21] Intercellular transfer and supramolecular organization of human leukocyte antigen C at inhibitory natural killer cell immune synapses [J].

Carlin, LM ;

Eleme, K ;

McCann, FE ;

Davis, DM .

JOURNAL OF EXPERIMENTAL MEDICINE, 2001, 194 (10) :1507-1517

[22]

CARPEN O, 1982, J IMMUNOL, V128, P2691

[23]

CARPEN O, 1983, J IMMUNOL, V131, P2695

[24] Organelle proteomics [J].

Casey, Tammy M. ;

Meade, Josephine L. ;

Hewitt, Eric W. .

MOLECULAR & CELLULAR PROTEOMICS, 2007, 6 (05) :767-780

[25] Asymmetric T lymphocyte division in the initiation of adaptive immune responses [J].

Chang, John T. ;

Palanivel, Vikram R. ;

Kinjyo, Ichiko ;

Schambach, Felix ;

Intlekofer, Andrew M. ;

Banerjee, Arnob ;

Longworth, Sarah A. ;

Vinup, Kristine E. ;

Mrass, Paul ;

Oliaro, Jane ;

Killeen, Nigel ;

Orange, Jordan S. ;

Russell, Sarah M. ;

Weninger, Wolfgang ;

Reiner, Steven L. .

SCIENCE, 2007, 315 (5819) :1687-1691

[26] Suppression of tumor formation in lymph nodes by L-selectin-mediated natural killer cell recruitment [J].

Chen, SH ;

Kawashima, H ;

Lowe, JB ;

Lanier, LL ;

Fukuda, M .

JOURNAL OF EXPERIMENTAL MEDICINE, 2005, 202 (12) :1679-1689

[27] CD28-stimulated ERK2 phosphorylation is required for polarization of the microtubule organizing center and granules in YTS NK cells [J].

Chen, Xi ;

Allan, David S. J. ;

Krzewski, Konrad ;

Ge, Baoxue ;

Kopcow, Hernan ;

Strominger, Jack L. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2006, 103 (27) :10346-10351

[28] Adaptor protein 3-dependent microtubule-mediated movement of lytic granules to the immunological synapse [J].

Clark, RH ;

Stinchcombe, JC ;

Day, A ;

Blott, E ;

Booth, S ;

Bossi, G ;

Hamblin, T ;

Davies, EG ;

Griffiths, GM .

NATURE IMMUNOLOGY, 2003, 4 (11) :1111-1120

[29] Recruitment of dynein to the Jurkat immunological synapse [J].

Combs, Jeffrey ;

Kim, Soo Jin ;

Tan, Sarah ;

Ligon, Lee A. ;

Holzbaur, Erika L. F. ;

Kuhn, Jeffrey ;

Poenie, Martin .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2006, 103 (40) :14883-14888

[30] The human natural killer cell immune synapse [J].

Davis, DM ;

Chiu, I ;

Fassett, M ;

Cohen, GB ;

Mandelboim, O ;

Strominger, JL .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1999, 96 (26) :15062-15067

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