Formation and function of the lytic NK-cell immunological synapse

被引：444

作者：

Orange, Jordan S. ^{[1
]}

机构：

[1] Univ Penn, Sch Med, Childrens Hosp Philadelphia, Joseph Stokes Jr Res Inst, Philadelphia, PA 19104 USA

来源：

NATURE REVIEWS IMMUNOLOGY | 2008年 / 8卷 / 09期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1038/nri2381

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The natural killer (NK)-cell immunological synapse is the dynamic interface formed between an NK cell and its target cell. Formation of the NK-cell immunological synapse involves several distinct stages, from the initiation of contact with a target cell to the directed delivery of lytic-granule contents for target-cell lysis. Progression through the individual stages is regulated, and this tight regulation underlies the precision with which NK cells select and kill susceptible target cells (including virally infected cells and cancerous cells) that they encounter during their routine surveillance of the body.

引用

页码：713 / 725

页数：13

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