[1] Kyorin Univ, Sch Med, Dept Pharmacol & Toxicol, Mitaka, Tokyo 181, Japan
[2] Nagoya Univ, Sch Med, Dept Clin Prevent Med, Nagoya, Aichi 466, Japan
[3] Tokyo Univ Agr & Technol, Fac Agr, Dept Vet Med, Tokyo, Japan
[4] Showa Univ, Sch Pharmaceut Sci, Dept Clin Pharm, Tokyo 142, Japan