Scope and limitations of solid-supported liquid-liquid extraction for the high-throughput purification of compound libraries

被引：40

作者：

Breitenbucher, JG ^{[1
]}

Arienti, KL ^{[1
]}

McClure, KJ ^{[1
]}

机构：

[1] RW Johnson Pharmaceut Res Inst, San Diego, CA 92121 USA

来源：

JOURNAL OF COMBINATORIAL CHEMISTRY | 2001年 / 3卷 / 06期

关键词：

D O I：

10.1021/cc010039f

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

This paper reports some of the advantages and limitations of solid-supported liquid-liquid extraction (SLE) for the rapid purification of organic compound libraries. Issues of solvent compatibility, compound compatibility, and technical methods are addressed. In addition the prospective use of calculated log P values is investigated to determine which impurities will be effectively removed by this technique. In addition SLE is shown to be complementary and in some cases superior to solid-phase extraction (SPE) methods for library purification. This is especially true when the desired products have functionality equivalent to that of the impurity to be removed.

引用

页码：528 / 533

页数：6

共 28 条

[1] Methodologies for generating solution-phase combinatorial libraries [J].

An, HY ;

Cook, PD .

CHEMICAL REVIEWS, 2000, 100 (09) :3311-3340

[2]

[Anonymous], COMMUNICATION

[3]

Bailey N, 1997, CHIMIA, V51, P832

[4] Higher order iminodiacetic acid libraries for probing protein-protein interactions [J].

Boger, DL ;

Goldberg, J ;

Jiang, WQ ;

Chai, WY ;

Ducray, P ;

Lee, JK ;

Ozer, RS ;

Andersson, CM .

BIOORGANIC & MEDICINAL CHEMISTRY, 1998, 6 (08) :1347-1378

[5] Generation of targeted C-2-symmetrical compound libraries by solution-phase combinatorial chemistry [J].

Boger, DL ;

Ozer, RS ;

Andersson, CM .

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 1997, 7 (14) :1903-1908

[6] Generalized dipeptidomimetic template: Solution phase parallel synthesis of combinatorial libraries [J].

Boger, DL ;

Tarby, CM ;

Myers, PL ;

Caporale, LH .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1996, 118 (08) :2109-2110

[7] Solid-phase library synthesis of alkoxyprolines [J].

Boldi, AM ;

Dener, JM ;

Hopkins, TP .

JOURNAL OF COMBINATORIAL CHEMISTRY, 2001, 3 (04) :367-373

[8] Titanium mediated reductive amination on solid support: Extending the utility of the 4-hydroxy-thiophenol linker [J].

Breitenbucher, JG ;

Hui, HC .

TETRAHEDRON LETTERS, 1998, 39 (45) :8207-8210

[9] Solid-phase synthesis of 4-aryl-1,4-dihydropyridines via the Hantzsch three component condensation [J].

Breitenbucher, JG ;

Figliozzi, G .

TETRAHEDRON LETTERS, 2000, 41 (22) :4311-4315

[10]

Breitenbucher JG, 1998, TETRAHEDRON LETT, V39, P1295

← 1 2 3 →