MSX-3D: a tool to validate 3D protein models using mass spectrometry

被引：16

作者：

Heymann, Michael ^{[1
]}

Paramelle, David ^{[2
,3
]}

Subra, Gilles ^{[2
,3
]}

Forest, Eric ^{[4
]}

Martinez, Jean ^{[2
,3
]}

Geourjon, Christophe ^{[1
]}

Deleage, Gilbert ^{[1
]}

机构：

[1] Univ Lyon 1, BioSci Lyon Gerland IFR128, CNRS, IBCP,UMR5086, F-69367 Lyon 07, France

[2] Univ Montpellier 1, CNRS, IBMM, UMR5247, F-34000 Montpellier, France

[3] Univ Montpellier 2, CNRS, IBMM, UMR5247, F-34000 Montpellier, France

[4] UJF, CNRS, CEA,Inst Biol Struct, Protein Mass Spectrometry Lab,UMR5075, F-38027 Grenoble 1, France

来源：

BIOINFORMATICS | 2008年 / 24卷 / 23期

关键词：

D O I：

10.1093/bioinformatics/btn510

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Motivation: The technique of chemical cross-linking followed by mass spectrometry has proven to bring valuable information about the protein structure and interactions between proteic subunits. It is an effective and efficient way to experimentally investigate some aspects of a protein structure when NMR and X-ray crystallography data are lacking. Results: We introduce MSX-3D, a tool specifically geared to validate protein models using mass spectrometry. In addition to classical peptides identifications, it allows an interactive 3D visualization of the distance constraints derived from a cross-linking experiment.

引用

页码：2782 / 2783

页数：2

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