Insights into tuberculosis from the zebrafish model

被引：39

作者：

Berg, Russell D. ^{[2
]}

Ramakrishnan, Lalita ^{[1
,3
,4
]}

机构：

[1] Univ Washington, Dept Microbiol, Seattle, WA 98195 USA

[2] Univ Washington, Dept Mol & Cell Biol, Seattle, WA 98195 USA

[3] Univ Washington, Dept Med, Seattle, WA 98195 USA

[4] Univ Washington, Dept Immunol, Seattle, WA 98195 USA

来源：

TRENDS IN MOLECULAR MEDICINE | 2012年 / 18卷 / 12期

关键词：

tuberculosis; zebrafish; Mycobacterium marinum; granuloma; MYCOBACTERIUM-MARINUM; INFECTION; GRANULOMA; PROTEIN;

D O I：

10.1016/j.molmed.2012.10.002

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Mycobacterium tuberculosis (MTB) continues to plague humanity because of significant gaps in our understanding of MTB infection, including the nature of a protective versus pathological host response, why antimicrobial cure is so difficult, and the ineffectiveness of vaccination. The development of a zebrafish model, utilizing infection with the natural fish pathogen Mycobacterium marinum (Mm), has yielded important insights into tuberculosis with immediate clinical applications.

引用

页码：689 / 690

页数：2

共 10 条

[1] Drug Tolerance in Replicating Mycobacteria Mediated by a Macrophage-Induced Efflux Mechanism [J].

Adams, Kristin N. ;

Takaki, Kevin ;

Connolly, Lynn E. ;

Wiedenhoft, Heather ;

Winglee, Kathryn ;

Humbert, Olivier ;

Edelstein, Paul H. ;

Cosma, Christine L. ;

Ramakrishnan, Lalita .

CELL, 2011, 145 (01) :39-53

[2] A High-Throughput Screen for Tuberculosis Progression [J].

Carvalho, Ralph ;

de Sonneville, Jan ;

Stockhammer, Oliver W. ;

Savage, Nigel D. L. ;

Veneman, Wouter J. ;

Ottenhoff, Tom H. M. ;

Dirks, Ron P. ;

Meijer, Annemarie H. ;

Spaink, Herman P. .

PLOS ONE, 2011, 6 (02)

[3] The Role of the Granuloma in Expansion and Dissemination of Early Tuberculous Infection [J].

Davis, J. Muse ;

Ramakrishnan, Lalita .

CELL, 2009, 136 (01) :37-49

[4] Insights from the complete genome sequence of Mycobacterium marinum on the evolution of Mycobacterium tuberculosis [J].

Stinear, Timothy P. ;

Seemann, Torsten ;

Harrison, Paul F. ;

Jenkin, Grant A. ;

Davies, John K. ;

Johnson, Paul D. R. ;

Abdellah, Zahra ;

Arrowsmith, Claire ;

Chillingworth, Tracey ;

Churcher, Carol ;

Clarke, Kay ;

Cronin, Ann ;

Davis, Paul ;

Goodhead, Ian ;

Holroyd, Nancy ;

Jagels, Kay ;

Lord, Angela ;

Moule, Sharon ;

Mungall, Karen ;

Norbertczak, Halina ;

Quail, Michael A. ;

Rabbinowitsch, Ester ;

Walker, Danielle ;

White, Brian ;

Whitehead, Sally ;

Small, Pamela L. C. ;

Brosch, Roland ;

Ramakrishnan, Lalita ;

Fischbach, Michael A. ;

Parkhill, Julian ;

Cole, Stewart T. .

GENOME RESEARCH, 2008, 18 (05) :729-741

[5] Comparative pathogenesis of Mycobacterium marinum and Mycobacterium tuberculosis [J].

Tobin, David M. ;

Ramakrishnan, Lalita .

CELLULAR MICROBIOLOGY, 2008, 10 (05) :1027-1039

[6] Host Genotype-Specific Therapies Can Optimize the Inflammatory Response to Mycobacterial Infections [J].

Tobin, David M. ;

Roca, Francisco J. ;

Oh, Sungwhan F. ;

McFarland, Ross ;

Vickery, Thad W. ;

Ray, John P. ;

Ko, Dennis C. ;

Zou, Yuxia ;

Bang, Nguyen D. ;

Chau, Tran T. H. ;

Vary, Jay C. ;

Hawn, Thomas R. ;

Dunstan, Sarah J. ;

Farrar, Jeremy J. ;

Thwaites, Guy E. ;

King, Mary-Claire ;

Serhan, Charles N. ;

Ramakrishnan, Lalita .

CELL, 2012, 148 (03) :434-446

[7] The lta4h Locus Modulates Susceptibility to Mycobacterial Infection in Zebrafish and Humans [J].

Tobin, David M. ;

Vary, Jay C., Jr. ;

Ray, John P. ;

Walsh, Gregory S. ;

Dunstan, Sarah J. ;

Bang, Nguyen D. ;

Hagge, Deanna A. ;

Khadge, Saraswoti ;

King, Mary-Claire ;

Hawn, Thomas R. ;

Moens, Cecilia B. ;

Ramakrishnan, Lalita .

CELL, 2010, 140 (05) :717-730

[8] The use of zebrafish to understand immunity [J].

Trede, NS ;

Langenau, DM ;

Traver, D ;

Look, AT ;

Zon, LI .

IMMUNITY, 2004, 20 (04) :367-379

[9] Unexpected Link between Lipooligosaccharide Biosynthesis and Surface Protein Release in Mycobacterium marinum [J].

van der Woude, Aniek D. ;

Sarkar, Debasmita ;

Bhatt, Apoorva ;

Sparrius, Marion ;

Raadsen, Susanne A. ;

Boon, Louis ;

Geurtsen, Jeroen ;

van der Sar, Astrid M. ;

Luirink, Joen ;

Houben, Edith N. G. ;

Besra, Gurdyal S. ;

Bitter, Wilbert .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2012, 287 (24) :20417-20429

[10] Tuberculous Granuloma Induction via Interaction of a Bacterial Secreted Protein with Host Epithelium [J].

Volkman, Hannah E. ;

Pozos, Tamara C. ;

Zheng, John ;

Davis, J. Muse ;

Rawls, John F. ;

Ramakrishnan, Lalita .

SCIENCE, 2010, 327 (5964) :466-469

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