Genome-Wide Association Study on the Development of Cross-Reactive Neutralizing Antibodies in HIV-1 Infected Individuals

被引：21

作者：

Euler, Zelda

van Gils, Marit J.

Boeser-Nunnink, Brigitte D.

Schuitemaker, Hanneke

van Manen, Danielle

机构：

[1] Univ Amsterdam, Acad Med Ctr, Dept Expt Immunol, Landsteiner Lab, NL-1105 AZ Amsterdam, Netherlands

[2] Univ Amsterdam, Acad Med Ctr, Ctr Infect Dis & Immun Amsterdam CINIMA, NL-1105 AZ Amsterdam, Netherlands

来源：

PLOS ONE | 2013年 / 8卷 / 01期

关键词：

HIV-1; INFECTION; DISEASE PROGRESSION; CLINICAL-COURSE; T-CELLS; VIRUS; NK; DETERMINANTS; EXPRESSION; ANTIGENS; BROAD;

D O I：

10.1371/journal.pone.0054684

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Broadly neutralizing antibodies may protect against HIV-1 acquisition. In natural infection, only 10-30% of patients have cross-reactive neutralizing humoral immunity which may relate to viral and or host factors. To explore the role of host genetic markers in the formation of cross-reactive neutralizing activity (CrNA) in HIV-1 infected individuals, we performed a genome-wide association study (GWAS), in participants of the Amsterdam Cohort Studies with known CrNA in their sera. Single-nucleotide polymorphisms (SNPs) with the strongest P-values are located in the major histocompatibility complex (MHC) region, close to MICA (P = 7.68 x 10(-7)), HLA-B (P = 6.96 x 10(-6)) and in the coding region of HCP5 (P = 1.34 x 10(-5)). However, none of the signals reached genome-wide significance. Our findings underline the potential involvement of genes close or within the MHC region with the development of CrNA.

引用

页数：7

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