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The INO80 chromatin remodeling complex in transcription, replication and repair

被引：143
作者：
Conaway, Ronald C. [1 ,2 ]
Conaway, Joan Weliky [1 ,2 ]
机构：
[1] Stowers Inst Med Res, Kansas City, MO 64110 USA
[2] Univ Kansas, Med Ctr, Dept Biochem & Mol Biol, Kansas City, KS 66160 USA
来源：
TRENDS IN BIOCHEMICAL SCIENCES | 2009年 / 34卷 / 02期
基金：
美国国家卫生研究院;
关键词：
ACTIN-RELATED PROTEINS; UCH37 DEUBIQUITINATING ENZYME; HOMOLOGOUS RECOMBINATION; DNA-BINDING; SACCHAROMYCES-CEREVISIAE; PROMOTER; BREAK; RECRUITMENT; PROTEASOME; SWR1;
D O I：
10.1016/j.tibs.2008.10.010
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The Ino80 ATPase is a member of the SNF2 family of ATPases and functions as an integral component of a multisubunit ATP-dependent chromatin remodeling complex. Although INO80 complexes from yeast and higher eukaryotes share a common core of conserved subunits, the complexes have diverged substantially during evolution and have acquired new subunits with apparently species-specific functions. Recent studies have shown that the INO80 complex contributes to a wide variety of chromatin-dependent nuclear transactions, including transcription, DNA repair and DNA replication.
引用
收藏
页码：71 / 77
页数：7
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