RETRACTED: Pyrenebutyrate-Mediated Delivery of Quantum Dots across the Plasma Membrane of Living Cells (Retracted Article. See vol 114, pg 9946, 2010)

被引：15

作者：

Jablonski, Amy E.

Humphries, William H.

Payne, Christine K. ^{[1
]}

机构：

[1] Georgia Inst Technol, Sch Chem & Biochem, Atlanta, GA 30332 USA

来源：

JOURNAL OF PHYSICAL CHEMISTRY B | 2009年 / 113卷 / 02期

关键词：

ARGININE-RICH PEPTIDES; PENETRATING PEPTIDES; LIVE CELLS; NUCLEAR DELIVERY; CELLULAR UPTAKE; TRACKING; INTERNALIZATION; NANOCRYSTALS; TRANSDUCTION; PROTEINS;

D O I：

10.1021/jp809956w

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

Quantum dots have been delivered directly across the plasma membrane to the cytosol of living cells using a combination of a cationic peptide, polyarginine, and a hydrophobic counterion, pyrenebutyrate. Quantum dot delivery did not disrupt the plasma membrane and bypassed the barrier of endocytic vesicles. Cellular uptake was independent of temperature but highly dependent oil the surface charge of the quantum dot and the membrane potential of the cell, suggesting a direct translocation across the membrane. This method of delivery can find immediate application for quantum dots and may be broadly applicable to other nanoparticles.

引用

页码：405 / 408

页数：4

共 44 条

[1] Endocytic traffic in polarized epithelial cells: Role of the actin and microtubule cytoskeleton [J].