Towards an HIV cure: a global scientific strategy

被引:430
作者
Deeks, Steven G. [1 ]
机构
[1] Univ Calif San Francisco, San Francisco, CA 94143 USA
关键词
CD4(+) T-CELLS; IMMUNODEFICIENCY-VIRUS TYPE-1; RALTEGRAVIR INTENSIFICATION; ANTIRETROVIRAL THERAPY; INFECTED INDIVIDUALS; IMMUNE ACTIVATION; ANTIVIRAL THERAPY; LATENT INFECTION; IN-VITRO; MODEL;
D O I
10.1038/nri3262
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Given the limitations of antiretroviral therapy and recent advances in our understanding of HIV persistence during effective treatment, there is a growing recognition that a cure for HIV infection is both needed and feasible. The International AIDS Society convened a group of international experts to develop a scientific strategy for research towards an HIV cure. Several priorities for basic, translational and clinical research were identified. This Opinion article summarizes the group's recommended key goals for the international community.
引用
收藏
页码:607 / 614
页数:8
相关论文
共 80 条
  • [1] Evidence for the cure of HIV infection by CCR5Δ32/Δ32 stem cell transplantation
    Allers, Kristina
    Huetter, Gero
    Hofmann, Joerg
    Loddenkemper, Christoph
    Rieger, Kathrin
    Thiel, Eckhard
    Schneider, Thomas
    [J]. BLOOD, 2011, 117 (10) : 2791 - 2799
  • [2] Impact of Multi-Targeted Antiretroviral Treatment on Gut T Cell Depletion and HIV Reservoir Seeding during Acute HIV Infection
    Ananworanich, Jintanat
    Schuetz, Alexandra
    Vandergeeten, Claire
    Sereti, Irini
    de Souza, Mark
    Rerknimitr, Rungsun
    Dewar, Robin
    Marovich, Mary
    van Griensven, Frits
    Sekaly, Rafick
    Pinyakorn, Suteeraporn
    Phanuphak, Nittaya
    Trichavaroj, Rapee
    Rutvisuttinunt, Wiriya
    Chomchey, Nitiya
    Paris, Robert
    Peel, Sheila
    Valcour, Victor
    Maldarelli, Frank
    Chomont, Nicolas
    Michael, Nelson
    Phanuphak, Praphan
    Kim, Jerome H.
    [J]. PLOS ONE, 2012, 7 (03):
  • [3] [Anonymous], 17 INT AIDS C MEX CI
  • [4] [Anonymous], UN UN ACC ZER NEW HI
  • [5] Immediate antiviral therapy appears to restrict resting CD4+ cell HIV-1 infection without accelerating the decay of latent infection
    Archin, Nancie M.
    Vaidya, Naveen K.
    Kuruc, JoAnn D.
    Liberty, Abigail L.
    Wiegand, Ann
    Kearney, Mary F.
    Cohen, Myron S.
    Coffin, John M.
    Bosch, Ronald J.
    Gay, Cynthia L.
    Eron, Joseph J.
    Margolis, David M.
    Perelson, Alan S.
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2012, 109 (24) : 9523 - 9528
  • [6] Expression of Latent HIV Induced by the Potent HDAC Inhibitor Suberoylanilide Hydroxamic Acid
    Archin, Nancie M.
    Espeseth, Amy
    Parker, Daniel
    Cheema, Manzoor
    Hazuda, Daria
    Margolis, David M.
    [J]. AIDS RESEARCH AND HUMAN RETROVIRUSES, 2009, 25 (02) : 207 - 212
  • [7] Reconsidering targeted toxins to eliminate HIV infection: You gotta have HAART
    Berger, EA
    Moss, B
    Pastan, I
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1998, 95 (20) : 11511 - 11513
  • [8] CpG Methylation Controls Reactivation of HIV from Latency
    Blazkova, Jana
    Trejbalova, Katerina
    Gondois-Rey, Francoise
    Halfon, Philippe
    Philibert, Patrick
    Guiguen, Allan
    Verdin, Eric
    Olive, Daniel
    Van Lint, Carine
    Hejnar, Jiri
    Hirsch, Ivan
    [J]. PLOS PATHOGENS, 2009, 5 (08)
  • [9] Homeostatic Proliferation Fails to Efficiently Reactivate HIV-1 Latently Infected Central Memory CD4+T Cells
    Bosque, Alberto
    Famiglietti, Marylinda
    Weyrich, Andrew S.
    Goulston, Claudia
    Planelles, Vicente
    [J]. PLOS PATHOGENS, 2011, 7 (10)
  • [10] Induction of HIV-1 latency and reactivation in primary memory CD4+ T cells
    Bosque, Alberto
    Planelles, Vicente
    [J]. BLOOD, 2009, 113 (01) : 58 - 65