The evolution of Staphylococcus aureus

被引:469
作者
Deurenberg, Ruud H. [1 ]
Stobberingh, Ellen E. [1 ]
机构
[1] Univ Hosp Maastricht, Dept Med Microbiol, NL-6229 HX Maastricht, Netherlands
关键词
CA-MRSA; HA-MRSA; MLST; MRSA; MSSA; PFGE; PVL; S; aureus; SCCmec; Spa typing;
D O I
10.1016/j.meegid.2008.07.007
中图分类号
R51 [传染病];
学科分类号
100401 ;
摘要
A broad variety of infections, ranging from minor infections of the skin to post-operative wound infections can be caused by Staphylococcus aureus. The adaptive power of S. aureus to antibiotics leaded, in the early 1960s, to the emergence of methicillin-resistant S. aureus (MRSA). The cause of resistance to methicillin and all other P-lactam antibiotics is the mecA gene, which is situated on a mobile genetic element, the staphylococcal cassette chromosome mec (SCCmec). Seven major variants of SCCmec, type I to VII, are distinguished. The most important techniques used to investigate the molecular epidemiology of S. aureus are pulsed-field gel electrophoresis (PFGE), multilocus sequence typing (MLST), S. aureus protein A (spa) typing and SCCmec typing (only for MRSA). These techniques have been used to study the evolution of the MRSA clones that have emerged since the early 1960s, and to study their subsequent worldwide dissemination. The early MRSA clones were hospital-associated (HA-MRSA). However, from the late 1990s, community-associated MRSA (CA-MRSA) clones emerged worldwide. CA-MRSA harbors SCCmec type IV, V or VII, the majority belong to other S. aureus lineages compared to HA-MRSA, and CA-MRSA is often associated with the presence of the toxin Panton-Valentine leukocidin (PVL). However, during recent years, the distinction between HA-MRSA and CA-MRSA has started to disappear, and CA-MRSA is now endemic in many US hospitals. MRSA probably originated trough the transfer of SCCmec into a limited number of methicillin-sensitive S. aureus (MSSA) lineages. This review describes the latest observations about the structure of SCCmec, the techniques used to Study the molecular epidemiology and evolution of S. aureus as well as some challenges that researchers face in the future. (C) 2008 Elsevier B.V. All rights reserved.
引用
收藏
页码:747 / 763
页数:17
相关论文
共 236 条
[1]  
AIRES DS, 2003, J CLIN MICROBIOL, V41, P3806
[2]   Unusually high prevalence of nosocomial Panton-Valentine leukocidin-positive Staphylococcus aureus isolates in Cape Verde islands [J].
Aires-de-Sousa, M. ;
Conceicao, T. ;
de Lencastre, H. .
JOURNAL OF CLINICAL MICROBIOLOGY, 2006, 44 (10) :3790-3793
[3]   High interlaboratory reproducibility of DNA sequence-based typing of bacteria in a multicenter study [J].
Aires-de-Sousa, M ;
Boye, K ;
de Lencastre, H ;
Deplano, A ;
Enright, MC ;
Etienne, J ;
Friedrich, A ;
Harmsen, D ;
Holmes, A ;
Huijsdens, XW ;
Kearns, AM ;
Mellmann, A ;
Meugnier, H ;
Rasheed, JK ;
Spalburg, E ;
Strommenger, B ;
Struelens, MJ ;
Tenover, FC ;
Thomas, J ;
Vogel, U ;
Westh, H ;
Xu, J ;
Witte, W .
JOURNAL OF CLINICAL MICROBIOLOGY, 2006, 44 (02) :619-621
[4]   Changes in the clonal nature and antibiotic resistance profiles of methicillin-resistant Staphylococcus aureus isolates associated with spread of the EMRSA-15 clone in a tertiary care Portuguese hospital [J].
Amorim, M. L. ;
Faria, N. A. ;
Oliveira, D. C. ;
Vasconcelos, C. ;
Cabeda, J. C. ;
Mendes, A. C. ;
Calado, E. ;
Castro, A. P. ;
Ramos, M. H. ;
Amorim, J. M. ;
de Lencastre, H. .
JOURNAL OF CLINICAL MICROBIOLOGY, 2007, 45 (09) :2881-2888
[5]   Methicillin-resistant Staphylococcus aureus in hospitals in Tbilisi, the Republic of Georgia, are variants of the Brazilian clone [J].
Bartels, M. D. ;
Nanuashvili, A. ;
Boye, K. ;
Rohde, S. M. ;
Jashiashvili, N. ;
Faria, N. A. ;
Kereselidze, M. ;
Kharebava, S. ;
Westh, H. .
EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES, 2008, 27 (08) :757-760
[6]   Rapid increase of genetically diverse methicillin-resistant Staphylocloccus aureus, Copenhagen, Denmark [J].
Bartels, Mette Damkjaer ;
Boye, Kit ;
Larsen, Anders Rhod ;
Skov, Robert ;
Westh, Henrik .
EMERGING INFECTIOUS DISEASES, 2007, 13 (10) :1533-1540
[7]   High prevalence of oxacillin-resistant Staphylococcus aureus isolates from hospitalized patients in Asia-Pacific and South Africa:: Results from SENTRY antimicrobial surveillance program, 1998-1999 [J].
Bell, JM ;
Turnidge, JD .
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2002, 46 (03) :879-881
[8]   Characterization of ST80 Panton-Valentine leukocidin-positive community-acquired methicillin-resistant Staphylococcus aureus clone in Tunisia [J].
Ben Nejma, Mouna ;
Mastouri, Maha ;
Jrad, Besma Bel Hadj ;
Nour, Mohamed .
DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE, 2013, 77 (01) :20-24
[9]   Presence of a novel DNA methylation enzyme in methicillin-resistant Staphylococcus aureus isolates associated with pig farming leads to uninterpretable results in standard pulsed-field gel electrophoresis analysis [J].
Bens, Corina C. P. M. ;
Voss, Andreas ;
Klaassen, Corne H. W. .
JOURNAL OF CLINICAL MICROBIOLOGY, 2006, 44 (05) :1875-1876
[10]   Factors influencing methicillin resistance in staphylococci [J].
Berger-Bächi, B ;
Rohrer, S .
ARCHIVES OF MICROBIOLOGY, 2002, 178 (03) :165-171