Alpha/beta and gamma interferons are induced by infection with noncytopathic bovine viral diarrhea virus in vivo

被引：54

作者：

Charleston, B ^{[1
]}

Brackenbury, LS ^{[1
]}

Carr, BV ^{[1
]}

Fray, MD ^{[1
]}

Hope, JC ^{[1
]}

Howard, CJ ^{[1
]}

Morrison, WI ^{[1
]}

机构：

[1] Inst Anim Hlth, Newbury RG20 7NN, Berks, England

来源：

JOURNAL OF VIROLOGY | 2002年 / 76卷 / 02期

关键词：

D O I：

10.1128/JVI.76.2.923-927.2002

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

In contrast to the results of previous in vitro studies, experimental infection of calves with noncytopathic bovine viral diarrhea virus (ncpBVDV) was found to induce strong alpha/beta and gamma interferon responses in gnotobiotic animals. These responses were associated with depressed levels of transforming growth factor beta (TGF-beta) in serum. The results of this study indicate that the immunosuppression caused by ncpBVDV is not associated with low interferon responses or elevated levels of TGF-beta.

引用

收藏

页码：923 / 927

页数：5

相关论文

共 24 条

[1] Functional diversity of helper T lymphocytes [J].

Abbas, AK ;

Murphy, KM ;

Sher, A .

NATURE, 1996, 383 (6603) :787-793

[2] Macrophages infected with cytopathic bovine viral diarrhea virus release a factor(s) capable of priming uninfected macrophages for activation-induced apoptosis [J].

Adler, B ;

Adler, H ;

Pfister, H ;

Jungi, TW ;

Peterhans, E .

JOURNAL OF VIROLOGY, 1997, 71 (04) :3255-3258

[3] CYTOKINES IN THE GENERATION OF IMMUNE-RESPONSES TO, AND RESOLUTION OF, VIRUS-INFECTION [J].

BIRON, CA .

CURRENT OPINION IN IMMUNOLOGY, 1994, 6 (04) :530-538

[4] Cellular responses to interferon-gamma [J].

Boehm, U ;

Klamp, T ;

Groot, M ;

Howard, JC .

ANNUAL REVIEW OF IMMUNOLOGY, 1997, 15 :749-795

[5] Transforming growth factor-beta induced by live or ultraviolet-inactivated equid herpes virus type-1 mediates immunosuppression in the horse [J].

Charan, S ;

Palmer, K ;

Chester, P ;

MireSluis, AR ;

Meager, A ;

Edington, N .

IMMUNOLOGY, 1997, 90 (04) :586-591

[6] CD4+ T-cell responses to bovine viral diarrhoea virus in cattle [J].

Collen, T ;

Morrison, WI .

VIRUS RESEARCH, 2000, 67 (01) :67-80

[7] SIMPLIFIED APPARATUS FOR MICROBIOLOGICAL ISOLATION OF CALVES [J].

DENNIS, MJ ;

DAVIES, DC ;

HOARE, MN .

BRITISH VETERINARY JOURNAL, 1976, 132 (06) :642-646

[8]

DIDERHOL.H, 1966, P SOC EXP BIOL MED, V121, P976, DOI 10.3181/00379727-121-30940

[9] Type I interferons and T helper development [J].

Farrar, JD ;

Murphy, KM .

IMMUNOLOGY TODAY, 2000, 21 (10) :484-489

[10] Transforming growth factor β in infectious disease:: always there for the host and the pathogen [J].

Fitzpatrick, DR ;

Bielefeldt-Ohmann, H .

TRENDS IN MICROBIOLOGY, 1999, 7 (06) :232-236