Alternative Reading Frame Supports An Alternative Model for Retinoblastoma

被引：2

作者：

Zacksenhaus, Eldad ^{[1
]}

机构：

[1] Univ Toronto, Dept Med, Div Cell & Mol Biol, Toronto Gen Res Inst,Univ Hlth Network, 67 Coll St,Rm 407, Toronto, ON M5G 2M1, Canada

来源：

CELL CYCLE | 2003年 / 2卷 / 01期

关键词：

Retinoblastoma; pRb; p53; ARF; Pituitary cancer;

D O I：

10.4161/cc.2.1.252

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The recent observation by Tyler Jacks' group that loss of ARF accelerates pituitary tumors in Rb+/-:Arf(-/-) mice by inducing proliferation without affecting apoptosis allows one to speculate about an alternative model for retinoblastoma. Retinoblasts in human and pituitary gland melanotrophs in the mouse might be uniquely susceptible to bi-allelic inactivation of Rb because upon loss-of-heterozygosity, these tissues are able to slowly proliferate without effectively activating the cell death machinery, and respond to an additional oncogenic signal. But what is the nature of this proliferation-permissive oncogenic alteration?

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页码：27 / 30

页数：4

相关论文

共 42 条

[1] p14ARF links the tumour suppressors RB and p53 [J].

Bates, S ;

Phillips, AC ;

Clark, PA ;

Stott, F ;

Peters, G ;

Ludwig, RL ;

Vousden, KH .

NATURE, 1998, 395 (6698) :124-125

[2] Metastasis genes: A progression puzzle [J].

Bernards, R ;

Weinberg, RA .

NATURE, 2002, 418 (6900) :823-823

[3] Signal-dependent protection from apoptosis in mice expressing caspase-resistant Rb [J].

Chau, BN ;

Borges, HL ;

Chen, TT ;

Masselli, A ;

Hunton, IC ;

Wang, YJY .

NATURE CELL BIOLOGY, 2002, 4 (10) :757-765

[4]

Chen D, 2002, CANCER RES, V62, P967

[5] Minimal regions of chromosomal imbalance in retinoblastoma detected by comparative genomic hybridization [J].

Chen, DN ;

Gallie, BL ;

Squire, JA .

CANCER GENETICS AND CYTOGENETICS, 2001, 129 (01) :57-63

[6] The INK4a/ARF tumor suppressor: one gene - two products - two pathways [J].

Chin, L ;

Pomerantz, J ;

DePinho, RA .

TRENDS IN BIOCHEMICAL SCIENCES, 1998, 23 (08) :291-296

[7] The retinoblastoma tumour suppressor in development and cancer [J].

Classon, M ;

Harlow, E .

NATURE REVIEWS CANCER, 2002, 2 (12) :910-917

[8] p107 and p130: Versatile proteins with interesting pockets [J].

Classon, M ;

Dyson, N .

EXPERIMENTAL CELL RESEARCH, 2001, 264 (01) :135-147

[9] Bcl-XL deamidation is a critical switch in the regulation of the response to DNA damage [J].

Deverman, BE ;

Cook, BL ;

Manson, SR ;

Niederhoff, RA ;

Langer, EM ;

Rosová, I ;

Kulans, LA ;

Fu, XY ;

Weinberg, JS ;

Heinecke, JW ;

Roth, KA ;

Weintraub, SJ .

CELL, 2002, 111 (01) :51-62

[10] The regulation of E2F by pRB-family proteins [J].

Dyson, N .

GENES & DEVELOPMENT, 1998, 12 (15) :2245-2262

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