Blinking statistics of a molecular beacon triggered by end-denaturation of DNA

被引：5

作者：

Ambjörnsson, T ^{[1
]}

Metzler, R ^{[1
]}

机构：

[1] NORDITA, Nord Inst Theoret Phys, DK-2100 Copenhagen O, Denmark

来源：

JOURNAL OF PHYSICS-CONDENSED MATTER | 2005年 / 17卷 / 49期

关键词：

D O I：

10.1088/0953-8984/17/49/022

中图分类号：

O469 [凝聚态物理学];

学科分类号：

070205 ;

摘要：

We use a master equation approach based on the Poland-Scheraga free energy for DNA denaturation to investigate the (un)zipping dynamics of a denaturation wedge in a stretch of DNA that is clamped at one end. In particular, we quantify the blinking dynamics of a fluorophore-quencher pair mounted within the denaturation wedge. We also Study the behavioural changes in the presence of proteins that selectively bind to single-stranded DNA. We show that Such a set-up could be well Suited as an easy-to-implement nanodevice for sensing environmental conditions in small volumes.

引用

页码：S4305 / S4316

页数：12

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