Synthesis of δ-amino acids with an ether linkage in the main chain and nucleobases on the side chain as monomer units for oxy-peptide nucleic acids

被引：23

作者：

Kuwahara, M ^{[1
]}

Arimitsu, M ^{[1
]}

Sisido, M ^{[1
]}

机构：

[1] Okayama Univ, Fac Engn, Dept Biosci & Biotechnol, Okayama 7008530, Japan

来源：

TETRAHEDRON | 1999年 / 55卷 / 33期

关键词：

peptide and polypeptide; nucleic acid analogues; amino acids and derivatives;

D O I：

10.1016/S0040-4020(99)00541-4

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Syntheses of four N-Fmoc delta-amino acids with an ether linkage in the main chain and four different nucleobases on the side chain, Fmoc-NH-C*H(CH2-CH2-B)-CH2-O-CH2-COOH (B = thymine, uracil, N-4-benzoylcytosine, and N-2-isobutyrylguanine) are described. The delta-amino acids were prepared through 8-12 step synthesis starting from L-homoserine and could be linked together to form novel peptide nucleic acids (oxy-PNAs = OPNAs). (C) 1999 Elsevier Science Ltd. All rights reserved.

引用

页码：10067 / 10078

页数：12

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