The paradoxical population genetics of Plasmodium falciparum

被引：37

作者：

Hartl, DL

Volkman, SK

Nielsen, KM

Barry, AE

Day, KP

Wirth, DF

Winzeler, EA

机构：

[1] Harvard Univ, Dept Organism & Evolutionary Biol, Cambridge, MA 02138 USA

[2] Harvard Univ, Sch Publ Hlth, Dept Immunol & Infect Dis, Boston, MA 02115 USA

[3] Univ Oxford, Dept Zool, Oxford OX1 3FY, England

[4] Scripps Res Inst, Dept Cell Biol, La Jolla, CA 92037 USA

来源：

TRENDS IN PARASITOLOGY | 2002年 / 18卷 / 06期

关键词：

D O I：

10.1016/S1471-4922(02)02268-7

中图分类号：

R38 [医学寄生虫学]; Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ; 100103 ;

摘要：

Among the leading causes of death in African children is cerebral malaria caused by the parasitic protozoan Plasmodium falciparum. Endemic forms of this disease are thought to have originated in central Africa 5000-10000 years ago, coincident with the innovation of slash-and-burn agriculture and the diversification of the Anopheles gambiae complex of mosquito vectors. Population genetic studies of P falciparum have yielded conflicting results. Some evidence suggests that today's population includes multiple ancient lineages pre-dating human speciation. Other evidence suggests that today's population derives from only one, or a small number, of these ancient lineages. Resolution of this issue is important for the evaluation of the long-term efficacy of drug and immunological control strategies.

引用

页码：266 / 272

页数：7

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