Polyphenols in chocolate, which have antioxidant activity, modulate immune functions in humans in vitro

被引:165
作者
Sanbongi, C
Suzuki, N
Sakane, T
机构
[1] ST MARIANNA UNIV,SCH MED,DEPT MED,KAWASAKI,KANAGAWA,JAPAN
[2] MEIJI SEIKA KAISHA LTD,BIO SCI LABS,SAITAMA,JAPAN
关键词
D O I
10.1006/cimm.1997.1109
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
We studied the effects of antioxidants from chocolate, cacao liquor polyphenol (CLP), on human immune functions in vitro. CLP is an enriched polyphenol fraction purified from cacao liquor that is a major component of chocolate. It has been shown that polyphenols have antioxidant activity, and reactive oxygen species (ROS) are involved in immune responses. CLP inhibited both hydrogen peroxide and superoxide anion, typical ROS, production by phorbol myristate acetate-activated granulocytes. CLP also inhibited menadione-induced production of both hydrogen peroxide and superoxide anion in normal human peripheral blood lymphocytes (PBL). CLP treatment of normal PEL in vitro inhibited mitogen-induced proliferation of T cells and polyclonal Ig production by B cells in a dose-dependent manner. CLP treatment inhibited both IL-2 mRNA expression of and IL-2 secretion by T cells. These results suggest that antioxidant CLP has immunoregulatory effects. (C) 1997 Academic Press.
引用
收藏
页码:129 / 136
页数:8
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