Solid-phase total synthesis of polymyxin B1

被引：27

作者：

Sharma, SK ^{[1
]}

Wu, AD ^{[1
]}

Chandramouli, N ^{[1
]}

Fotsch, C ^{[1
]}

Kardash, G ^{[1
]}

Bair, KW ^{[1
]}

机构：

[1] Novartis Inst Biomed Res, Dept Oncol, Summit, NJ 07901 USA

来源：

JOURNAL OF PEPTIDE RESEARCH | 1999年 / 53卷 / 05期

关键词：

Fmoc-Dab(Dde); polymyxin B1; S-(+)-6-methyloctane-1-carboxylic acid; solid-phase synthesis;

D O I：

10.1034/j.1399-3011.1999.00045.x

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

The total solid-phase synthesis of polymyxin B1 (PMB1) has been achieved in 20% yield using the orthogonal protecting group N-1-(4,4-dimethyl-2,6-dioxocyclohexylidene)ethyl-(Dde). This report demonstrates that a complex peptide macrocycle can be synthesized in high yields using solid-phase synthesis. According to MS and HPLC, the synthetic peptide was identical to the naturally occurring antibiotic.

引用

页码：501 / 506

页数：6

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