Aging of the immune system: How much can the adaptive immune system adapt?

被引：335

作者：

Weng, NP ^{[1
]}

机构：

[1] NIA, Immunol Lab, NIH, Baltimore, MD 21224 USA

来源：

IMMUNITY | 2006年 / 24卷 / 05期

关键词：

D O I：

10.1016/j.immuni.2006.05.001

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The competency of the adaptive immune function decreases with age, primarily because of the decline in production of naive lymphocytes in the bone marrow and thymus as well as the expansion of incompetent memory lymphocytes. Here I discuss the recent progress on age-associated changes in lymphocytes and their effect on the adaptive immune system.

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页码：495 / 499

页数：5

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