Enantio selective desymmetrization of meso bicyclic hydrazines: A novel approach to the asymmetric synthesis of polysubstituted amino cyclopentanic cores

被引：55

作者：

Luna, AP

Ceschi, MA

Bonin, M

Micouin, L

Husson, HP

Gougeon, S

Estenne-Bouhtou, G

Marabout, B

Sevrin, M

George, P

机构：

[1] CNRS, Chim Therapeut Lab, UMR 8638, F-75270 Paris 06, France

[2] Univ Paris 05, Fac Sci Pharmaceut & Biol, F-75270 Paris, France

[3] Sanofi Rech, Synthelabo, Dept Rech Syst Nerveux Cent, F-92220 Bagneux, France

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2002年 / 67卷 / 10期

关键词：

D O I：

10.1021/jo011190e

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Catalytic asymmetric hydroboration can be successfully applied to meso bicyclic hydrazines. The resulting alcohols are of great synthetic interest and can lead in a straightforward manner to cyclopentanic diamino alcohols with good enantiomeric purity.

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页码：3522 / 3524

页数：3

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