Genomic structure of human omentin, a new adipocytokine expressed in omental adipose tissue

被引：282

作者：

Schäffler, A

Neumeier, A

Herfarth, H

Fürst, A

Schölmerich, J

Büchler, C

机构：

[1] Univ Regensburg, Dept Internal Med 1, D-93042 Regensburg, Germany

[2] Univ Regensburg, Dept Surg, D-93042 Regensburg, Germany

来源：

BIOCHIMICA ET BIOPHYSICA ACTA-GENE STRUCTURE AND EXPRESSION | 2005年 / 1732卷 / 1-3期

关键词：

omentin; intelectin; adipocyte; chronic inflammatory bowel disease; Crohn's disease;

D O I：

10.1016/j.bbaexp.2005.11.005

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Genomic structure, promoter region, amino acid sequence and exon-specific primer combinations of the human omentin gene are presented. Omentin mRNA expression differs between omental adipose tissue probes from patients with chronic inflammatory bowel diseases such as Crohn's disease. Sequence comparisons revealed a 100% identity of omentin with human intelectin. Based on this, omentin might be a new adipocytokine playing a role in the defense against intestinal bacterial translocation in the context of Crohn's disease. (c) 2005 Elsevier B.V. All rights reserved.

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页码：96 / 102

页数：7

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