A Peptide Nanofibrous Indicator for Eye-Detectable Cancer Cell Identification

被引：33

作者：

Chen, Chang-Sheng ^{[1
,2
]}

Xu, Xiao-Ding ^{[1
,2
]}

Wang, Ya ^{[1
,2
]}

Yang, Juan ^{[1
,2
]}

Jia, Hui-Zhen ^{[1
,2
]}

Cheng, Han ^{[1
,2
]}

Chu, Chih-Chang ^{[3
,4
]}

Zhuo, Ren-Xi ^{[1
,2
]}

Zhang, Xian-Zheng ^{[1
,2
]}

机构：

[1] Wuhan Univ, Minist Educ, Key Lab Biomed Polymers, Wuhan 430072, Peoples R China

[2] Wuhan Univ, Dept Chem, Wuhan 430072, Peoples R China

[3] Cornell Univ, Dept Fiber Sci & Apparel Design, Ithaca, NY 14853 USA

[4] Cornell Univ, Dept Biomed Engn, Ithaca, NY 14853 USA

来源：

SMALL | 2013年 / 9卷 / 06期

基金：

中国国家自然科学基金;

关键词：

cancer cells; diagnostics; nanofibers; peptides; self-assembly; CHEMISTRY; EXPRESSION; SENSORS;

D O I：

10.1002/smll.201201928

中图分类号：

O6 [化学];

学科分类号：

070301 [无机化学];

摘要：

A unique peptide nanofibrous indicator (NFI) is fabricated by mixing a borono-peptide with alizarin red S, followed by subsequent binding and self-assembly. The NFI thus obtained exhibits an intense response to sialyl Lewis X tetrasaccharide, which is overexpressed in human hepatocellular carcinoma cell lines. Importantly, this NFI has the capability of specifically recognizing human hepatocellular liver carcinoma (HepG2) cells through the eye-detectable color change resulting from strong binding-induced displacement. This novel technique for cancer cell identification through direct unaided eye judgment will open up an innovative platform for cancer cell detection.

引用

页码：920 / 926

页数：7

共 35 条

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Supramolecular Host-Guest Interaction for Labeling and Detection of Cellular Biomarkers [J].