Detection of a Prognostic Indicator in Early-Stage Cancer Using Functionalized Graphene-Based Peptide Sensors

被引：134

作者：

Feng, Lingyan ^{[1
]}

Wu, Li ^{[1
]}

Wang, Jiasi ^{[1
]}

Ren, Jinsong ^{[1
]}

Miyoshi, Daisuke ^{[2
]}

Sugimoto, Naoki ^{[2
]}

Qu, Xiaogang ^{[1
]}

机构：

[1] Chinese Acad Sci, Changchun Inst Appl Chem, State Key Lab Rare Earth Resource Utilizat, Biol Chem Lab,Grad Sch,Div Biol Inorgan Chem, Changchun 130022, Jilin, Peoples R China

[2] Konan Univ, FIBER, Higashinada Ku, Kobe, Hyogo 6588501, Japan

来源：

ADVANCED MATERIALS | 2012年 / 24卷 / 01期

关键词：

peptide sensor; cyclin A2; electrochemistry; impedance; graphene; HUMAN CYCLIN A(2); NONCOVALENT FUNCTIONALIZATION; CATALYTIC-ACTIVITY; CARBON NANOTUBES; OXIDE; EXPRESSION; MARKER; DIFFERENTIATION; MICROARRAYS; BIOSENSORS;

D O I：

10.1002/adma.201103205

中图分类号：

O6 [化学];

学科分类号：

070301 [无机化学];

摘要：

Using a porphyrin-functionalized graphenemodifi ed electrode, an electrochemical impedance peptide sensor for labelfree detection of cyclin A2 has been constructed. This electrochemical sensor can not only detect protein in cancer cells but also differentiate cancer cells from normal ones. Furthermore, the assay provides the potential of using a simple electrochemical technique to estimate the effi ciency of anticancer drugs in cancer therapy.

引用

收藏

页码：125 / +

页数：8

相关论文

共 69 条

[1]

Honeycomb Carbon: A Review of Graphene [J].

Allen, Matthew J. ;

Tung, Vincent C. ;

Kaner, Richard B. .

CHEMICAL REVIEWS, 2010, 110 (01) :132-145

[2]

On the concentrations of cyclins and cyclin-dependent kinases in extracts of cultured human cells [J].

Arooz, T ;

Yam, CH ;

Siu, WY ;

Lau, A ;

Li, KKW ;

Poon, RYC .

BIOCHEMISTRY, 2000, 39 (31) :9494-9501

[3]

Real-time label-free monitoring of adipose-derived stem cell differentiation with electric cell-substrate impedance sensing [J].

Bagnaninchi, Pierre O. ;

Drummond, Nicola .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2011, 108 (16) :6462-6467

[4]

Graphene Platform for Hairpin-DNA-Based Impedimetric Genosensing [J].

Bonanni, Alessandra ;

Pumera, Martin .

ACS NANO, 2011, 5 (03) :2356-2361

[5]

Pseudo 3D single-walled carbon nanotube film for BSA-free protein chips [J].

Byon, HR ;

Hong, BJ ;

Gho, YS ;

Park, JW ;

Choi, HC .

CHEMBIOCHEM, 2005, 6 (08) :1331-1334

[6]

Identification of an hexapeptide that binds to a surface pocket in cyclin A and inhibits the catalytic activity of the complex cyclin-dependent kinase 2-cyclin A [J].

Canela, Nuria ;

Orzaez, Mar ;

Fucho, Raquel ;

Mateo, Francesca ;

Gutierrez, Ricardo ;

Pineda-Lucena, Antonio ;

Bachs, Oriol ;

Perez-Paya, Enrique .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2006, 281 (47) :35942-35953

[7]

Chao Y, 1998, CANCER RES, V58, P985

[8]

Noncovalent functionalization of carbon nanotubes for highly specific electronic biosensors [J].

Chen, RJ ;

Bangsaruntip, S ;

Drouvalakis, KA ;

Kam, NWS ;

Shim, M ;

Li, YM ;

Kim, W ;

Utz, PJ ;

Dai, HJ .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2003, 100 (09) :4984-4989

[9]

A noncovalent approach to the construction of tween 20-based protein microarrays [J].

Chi, Young Shik ;

Byon, Hye Ryung ;

Choi, Hee Cheul ;

Choi, Insung S. .

CHEMBIOCHEM, 2007, 8 (12) :1380-1387

[10]

Analytical performance and characterization of MPA-Gly-Gly-His modified sensors [J].

Chow, E ;

Wong, ELS ;

Böcking, T ;

Nguyen, QT ;

Hibbert, DB ;

Gooding, JJ .

SENSORS AND ACTUATORS B-CHEMICAL, 2005, 111 :540-548

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