Intracellular Distribution of Macrophage Targeting Ferritin-Iron Oxide Nanocomposite

被引：37

作者：

Uchida, Masaki ^{[3
,4
]}

Willits, Deborah A. ^{[4
,5
]}

Muller, Karin ^{[6
]}

Willis, Ann F. ^{[3
,4
]}

Jackiw, Larissa ^{[7
]}

Jutila, Mark ^{[7
]}

Young, Mark J. ^{[4
,5
]}

Porter, Alexandra E. ^{[1
,2
]}

Douglas, Trevor ^{[3
,4
]}

机构：

[1] Univ London Imperial Coll Sci Technol & Med, Dept Mat, London SW7 2AZ, England

[2] SuperSTEM, Daresbury Lab, Warrington WA4 4AD, Cheshire, England

[3] Montana State Univ, Dept Chem & Biochem, Bozeman, MT 59717 USA

[4] Montana State Univ, Ctr Bioinspired Nanomat, Bozeman, MT 59717 USA

[5] Montana State Univ, Dept Plant Sci, Bozeman, MT 59717 USA

[6] Univ Cambridge, Dept Physiol Dev & Neurosci, Multiimaging Ctr, Cambridge CB2 3DY, England

[7] Montana State Univ, Dept Vet Mol Biol, Bozeman, MT 59717 USA

来源：

ADVANCED MATERIALS | 2009年 / 21卷 / 04期

基金：

美国国家卫生研究院;

关键词：

SHOCK-PROTEIN CAGE; DRUG-DELIVERY; ELECTRON TOMOGRAPHY; CELLS; NANOPARTICLES; INTEGRIN; PLATFORM; ALPHA(V)BETA(3); PHAGOCYTOSIS; MICROSCOPY;

D O I：

10.1002/adma.200801209

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Intracellular distribution of iron oxide nanoparticles incorporated within a ferritin mutant that displays genetically introduced cell-targeted peptides (RGD-4C) on its exterior surface are investigated using scanning transmission electron microscopy with a high-angle annular dark-field detector. The particles (indicated by arrows) internalized into macrophages much more effectively than those with noncell-targeted ferritin.

引用

页码：458 / +

页数：6

共 30 条

[1] Gadolinium chelate coated gold nanoparticles as contrast agents for both X-ray computed tomography and magnetic resonance imaging [J].

Alric, Christophe ;

Taleb, Jacqueline ;

Le Duc, Geraldine ;

Mandon, Celine ;

Billotey, Claire ;

Le Meur-Herland, Alice ;

Brochard, Thierry ;

Vocanson, Francis ;

Janier, Marc ;

Perriat, Pascal ;

Roux, Stephane ;

Tillement, Olivier .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2008, 130 (18) :5908-5915

[2] Regulation of macrophage foam cell formation by αVβ3 integrin -: Potential role in human atherosclerosis [J].

Antonov, AS ;

Kolodgie, FD ;

Munn, DH ;

Gerrity, RG .

AMERICAN JOURNAL OF PATHOLOGY, 2004, 165 (01) :247-258

[3] Cancer treatment by targeted drug delivery to tumor vasculature in a mouse model [J].

Arap, W ;

Pasqualini, R ;

Ruoslahti, E .

SCIENCE, 1998, 279 (5349) :377-380

[4] Quantification of the expression level of integrin receptor αVβ3 in cell lines and MR imaging with antibody-coated iron oxide particles [J].

Benedetto, Sabrina ;

Pulito, Roberta ;

Crich, Simonetta Geninatti ;

Tarone, Guido ;

Aime, Silvio ;

Silengo, Lorenzo ;

Hamm, Jorg .

MAGNETIC RESONANCE IN MEDICINE, 2006, 56 (04) :711-716

[5]

Byzova TV, 1998, THROMB HAEMOSTASIS, V80, P726

[6] Nanotechnology: Intelligent design to treat complex disease [J].

Couvreur, Patrick ;

Vauthier, Christine .

PHARMACEUTICAL RESEARCH, 2006, 23 (07) :1417-1450

[7] Viruses: Making friends with old foes [J].

Douglas, T ;

Young, M .

SCIENCE, 2006, 312 (5775) :873-875

[8] Integrin-dependent phagocytosis - spreading from microadhesion to new concepts [J].

Dupuy, Aurelien G. ;

Caron, Emmanuelle .

JOURNAL OF CELL SCIENCE, 2008, 121 (11) :1773-1783

[9] The pinpoint promise of nanoparticle-based drug delivery and molecular diagnosis [J].

Emerich, Dwaine F. ;

Thanos, Christopher G. .

BIOMOLECULAR ENGINEERING, 2006, 23 (04) :171-184

[10] Nanomedicine: Developing smarter therapeutic and diagnostic modalities [J].

Farokhzad, Omid C. ;

Langer, Robert .

ADVANCED DRUG DELIVERY REVIEWS, 2006, 58 (14) :1456-1459

← 1 2 3 →