Ring closing metathesis for the formation of medium ring ethers: the total synthesis of (-)-isolaurallene

被引：63

作者：

Crimmins, MT ^{[1
]}

Emmitte, KA ^{[1
]}

Choy, AL ^{[1
]}

机构：

[1] Univ N Carolina, Venable & Kenan Labs Chem, Chapel Hill, NC 27599 USA

来源：

TETRAHEDRON | 2002年 / 58卷 / 10期

基金：

美国国家卫生研究院;

关键词：

marine natural products; isolaurallene; metathesis; asymmetric aldol; asymmetric alkylation; oxonene;

D O I：

10.1016/S0040-4020(02)00040-6

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The total synthesis of the marine metabolite (-)-isolaurallene is described. Two approaches to the core nine-membered ether are presented both of which are based on a ring closing metathesis to close the cyclic ether. (C) 2002 Published by Elsevier Science Ltd.

引用

页码：1817 / 1834

页数：18

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