Design and modular parallel synthesis of a MCR derived α-helix mimetic protein-protein interaction inhibitor scaffold

被引：43

作者：

Antuch, W

Menon, S

Chen, QZ

Lu, YC

Sakamuri, S

Beck, B

Schauer-Vukasinovic, V

Agarwal, S

Hess, S

Dömling, A

机构：

[1] ABC Pharma, D-81243 Munich, Germany

[2] Morphochem AG, D-81379 Munich, Germany

[3] Morphochem Inc, Monmouth Jct, NJ USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2006年 / 16卷 / 06期

关键词：

protein interaction antagonist; cancer; Bc1; family; apoptosis; multicomponent reaction; isocyanide;

D O I：

10.1016/j.bmcl.2005.11.102

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A terphenyl alpha-helix mimetic scaffold recognized to be capable of disrupting protein-protein interactions was structurally morphed into an easily amenable and versatile multicomponent reaction (MCR) backbone. The design, modular in-parallel library synthesis, initial cell based biological data, and preliminary in vitro screening for the disruption of the Bcl-w/Bak protein-protein interaction by representatives of the MCR derived scaffold are presented. (C) 2006 Published by Elsevier Ltd.

引用

页码：1740 / 1743

页数：4

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