Biphenyls as potential mimetics of protein α-helix

被引：53

作者：

Jacoby, E ^{[1
]}

机构：

[1] Novartis Pharma AG, Combinatorial Chem Unit, CH-4002 Basel, Switzerland

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2002年 / 12卷 / 06期

关键词：

D O I：

10.1016/S0960-894X(02)00031-8

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Based on theoretical arguments, 2,6,3',5'-substituted biphenyl analogues are proposed as protein alpha-helix mimetics superimposing the side chains of the residues i, i + 1, i + 3 and i + 4. Knowing that many protein-protein interactions of therapeutical relevance involve alpha-helix contacts, the communication outlines how this novel category of scaffolds might potentially open access to such targets. (C) 2002 Elsevier Science Ltd. All rights reserved.

引用

页码：891 / 893

页数：3

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