HLA class II associated risk and protection against multiple sclerosis -: a Finnish family study

被引：58

作者：

Laaksonen, M

Pastinen, T

Sjöroos, M

Kuokkanen, S

Ruutiainen, J

Sumelahti, ML

Reijonen, H

Salonen, R

Wikström, J

Panelius, M

Partanen, J

Tienari, PJ

Ilonen, J

机构：

[1] Univ Turku, Ctr Immunol, FIN-20520 Turku, Finland

[2] Univ Turku, Dept Virol, FIN-20520 Turku, Finland

[3] Natl Publ Hlth Inst, Helsinki, Finland

[4] Masku Neurol Rehabil Ctr, Masku, Finland

[5] Univ Tampere, Sch Publ Hlth, FIN-33101 Tampere, Finland

[6] Univ Turku, Dept Neurol, FIN-20520 Turku, Finland

[7] Univ Helsinki, Dept Neurol, Helsinki, Finland

[8] Finnish Red Cross & Blood Transfus Serv, SF-00310 Helsinki, Finland

来源：

JOURNAL OF NEUROIMMUNOLOGY | 2002年 / 122卷 / 1-2期

关键词：

multiple sclerosis; genetics; HLA class II-region; protection; family study;

D O I：

10.1016/S0165-5728(01)00456-8

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

We analyzed the HLA class II haplotypes in 249 Finnish nuclear families and compared the frequencies of parental haplotypes transmitted or non-transmitted to multiple sclerosis (MS) patients. The most important predisposing haplotype was DRB1 * 15-DQB1 * 0602 (p<10(-6)) as expected and a weak predisposing effect of DRB1 * 04-DQB1 * 0302 was revealed after the elimination of DRB1 * 15-DQB1 * 0602. HLA-DRB1 * 01-DQB1 * 0501 and DRB1 * 13-DQB1 * 0603 were negatively associated with MS in transmission disequilibrium, test, but only the DRB1 * 13-DQB1 * 0603 association remained significant (P=0.008) after the elimination of DRB1 * 15-DQB1 * 0602 haplotypes. Based on this study HLA class II haplotypes exhibit both predisposing and protective effects in MS. (C) 2002 Elsevier Science B.V. All rights reserved.

引用

页码：140 / 145

页数：6

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