Hydrogels Incorporating GdDOTA: Towards Highly Efficient Dual T1/T2 MRI Contrast Agents

被引：150

作者：

Courant, Thomas ^{[1
,2
]}

Roullin, Valerie Gaelle ^{[1
]}

Cadiou, Cyril ^{[2
]}

Callewaert, Maite ^{[1
]}

Andry, Marie Christine ^{[1
]}

Portefaix, Christophe ^{[3
]}

Hoeffel, Christine ^{[3
]}

de Goltstein, Marie Christine ^{[4
]}

Port, Marc ^{[4
]}

Laurent, Sophie ^{[5
]}

Vander Elst, Luce ^{[5
]}

Muller, Robert ^{[5
,6
]}

Molinari, Michael ^{[7
]}

Chuburu, Francoise ^{[2
]}

机构：

[1] Univ Reims, Inst Chim Mol Reims, CNRS UMR 7312, UFR Pharm, F-51100 Reims, France

[2] Univ Reims, Inst Chim Mol Reims, CNRS UMR 7312, F-51687 Reims 2, France

[3] CHU Reims Hop Maison Blanche, Serv Radiol, F-51092 Reims, France

[4] GUERBET, F-95943 Roissy, France

[5] Univ Mons, NMR & Mol Imaging Lab, Dept Gen Organ & Biomed Chem, B-7000 Mons, Belgium

[6] Ctr Microscopy & Mol Imaging, B-6041 Charleroi, Belgium

[7] EA4682 Univ Reims Champagne Ardenne, Lab Rech Nanosci, F-51685 Reims 2, France

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2012年 / 51卷 / 36期

关键词：

T1; T2 contrast agents; gadolinium; gels; imaging agents; nanoparticles; GOLD NANOPARTICLES; GADOLINIUM CHELATE; PARTICLES; LIPOSOMES; T-1;

D O I：

10.1002/anie.201203190

中图分类号：

O6 [化学];

学科分类号：

070301 [无机化学];

摘要：

Do not tumble dry: Gadolinium-DOTA encapsulated into polysaccharide nanoparticles (GdDOTNPs) exhibited high relaxivity (r1=101.7 s -1 mM-1 per Gd3+ ion at 37 °C and 20 MHz). This high relaxation rate is due to efficient Gd loading, reduced tumbling of the Gd complex, and the hydrogel nature of the nanoparticles. The efficacy of the nanoparticles as a T1/T2 dual-mode contrast agent was studied in C6 cells (see picture). Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

引用

页码：9119 / 9122

页数：4

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