KPC-4 Is Encoded within a Truncated Tn4401 in an IncL/M Plasmid, pNE1280, Isolated from Enterobacter cloacae and Serratia marcescens

被引：49

作者：

Bryant, Kendall A. ^{[1
]}

Van Schooneveld, Trevor C. ^{[2
]}

Thapa, Ishwor ^{[3
]}

Bastola, Dhundy ^{[3
]}

Williams, Laurina O. ^{[4
]}

Safranek, Thomas J. ^{[5
]}

Hinrichs, Steven H. ^{[1
]}

Rupp, Mark E. ^{[2
]}

Fey, Paul D. ^{[1
,2
]}

机构：

[1] Univ Nebraska Med Ctr, Dept Pathol & Microbiol, Omaha, NE 68198 USA

[2] Univ Nebraska Med Ctr, Dept Internal Med, Omaha, NE USA

[3] Univ Nebraska Omaha, Coll Informat Sci & Technol, Omaha, NE USA

[4] Ctr Dis Control & Prevent, Div Lab Sci & Stand, Atlanta, GA USA

[5] Nebraska Dept Hlth & Human Serv, Lincoln, NE USA

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2013年 / 57卷 / 01期

关键词：

HYDROLYZING BETA-LACTAMASE; KLEBSIELLA-PNEUMONIAE; BLA(KPC); EPIDEMIOLOGY; SEQUENCE; SALMONELLA; EMERGENCE; STRAIN; ST258;

D O I：

10.1128/AAC.01062-12

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

We describe the transfer of bla(KPC-4) from Enterobacter cloacae to Serratia marcescens in a single patient. DNA sequencing revealed that KPC-4 was encoded on an IncL/M plasmid, pNE1280, closely related to pCTX-M360. Further analysis found that KPC-4 was encoded within a novel Tn4401 element (Tn4401f) containing a truncated tnpA and lacking tnpR, ISKpn7 left, and Tn4401 IRL-1, which are conserved in other Tn4401 transposons. This study highlights the continued evolution of Tn4401 transposons and movement to multiple plasmid backbones that results in acquisition by multiple species of Gram-negative bacilli.

引用

页码：37 / 41

页数：5

共 32 条

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