Organization, structure and evolution of the CYP2 gene cluster on human chromosome 19

被引：106

作者：

Hoffman, SMG ^{[1
]}

Nelson, DR

Keeney, DS

机构：

[1] Miami Univ, Dept Zool, Oxford, OH 45056 USA

[2] Univ Tennessee, Dept Biochem, Memphis, TN USA

[3] Vanderbilt Univ, Sch Med, Dept Med, Nashville, TN 37212 USA

[4] Vanderbilt Univ, Sch Med, Dept Biochem, Nashville, TN 37212 USA

[5] Tennessee Valley Hlth Care Syst, Nashville, TN USA

来源：

PHARMACOGENETICS | 2001年 / 11卷 / 08期

关键词：

CYP2A; CYP2B; CYP2F; CYP2G; CYP2S; CYP2T; cytochrome P450; gene duplication; gene family;

D O I：

10.1097/00008571-200111000-00007

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

The cytochrome P450 superfamily of mixed-function oxygenases has been extensively studied due to its many critical metabolic roles, and also because it is a fascinating example of gene family evolution. The cluster of genes on human chromosome 19 from the CYP2A, 2B, and 2F subfamilies has been previously described as having a complex organization and many pseudogenes. We describe the discovery of genes from three more CYP2 subfamilies inside the cluster, and assemble a complete map of the region. We comprehensively review the organization, structure, and expression of genes from all six subfamilies. A general hypothesis for the evolution of this complex gene cluster is also presented. Pharmacogenetics 11:687-698 (C) 2001 Lippincott Williams & Wilkins.

引用

页码：687 / 698

页数：12

共 88 条

[1] LACK OF THE STEROID 15-ALPHA-HYDROXYLASE GENE (CYP2A-4) IN WILD MOUSE STRAIN MUS-SPRETUS - RAPID EVOLUTION OF THE P450 GENE SUPERFAMILY [J].