Simple Disk-Based Method for Detection of Klebsiella pneumoniae Carbapenemase-Type β-Lactamase by Use of a Boronic Acid Compound

被引：130

作者：

Doi, Yohei ^{[1
]}

Potoski, Brian A. ^{[1
,2
]}

Adams-Haduch, Jennifer M. ^{[1
]}

Sidjabat, Hanna E. ^{[1
]}

Pasculle, Anthony W. ^{[1
,3
]}

Paterson, David L. ^{[1
,4
,5
]}

机构：

[1] Univ Pittsburgh, Med Ctr, Div Infect Dis, Pittsburgh, PA 15261 USA

[2] Univ Pittsburgh, Med Ctr, Antibiot Management Program, Pittsburgh, PA 15261 USA

[3] Univ Pittsburgh, Med Ctr, Clin Microbiol Lab, Pittsburgh, PA 15261 USA

[4] Univ Queensland, UQ Ctr Clin Res, Brisbane, Qld, Australia

[5] Royal Brisbane & Womens Hosp, Brisbane, Qld, Australia

来源：

JOURNAL OF CLINICAL MICROBIOLOGY | 2008年 / 46卷 / 12期

关键词：

D O I：

10.1128/JCM.01408-08

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

A disk potentiation method using carbapenems as substrates and 3-aminophenyl boronic acid as an inhibitor was evaluated for the detection of Klebsiella pneumoniae carbapenemase (KPC)-type beta-lactamases. When combined with nonsusceptibility to ertapenem, the method was easy to perform and reliably differentiated isolates producing KPC-type beta-lactamases from those producing other types of beta-lactamases.

引用

页码：4083 / 4086

页数：4

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