The effect of absorbing resins on substrate concentration and enantiomeric excess in yeast reduction

被引：55

作者：

DArrigo, P

Fantoni, GP

Servi, S

Strini, A

机构：

[1] CNR,CTR STUDIO SOSTANZE ORGAN NAT,I-20131 MILAN,ITALY

[2] POLITECN MILAN,DIPARTIMENTO CHIM,I-20131 MILAN,ITALY

来源：

TETRAHEDRON-ASYMMETRY | 1997年 / 8卷 / 14期

关键词：

D O I：

10.1016/S0957-4166(97)00257-7

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

The correlation between the enantiomeric excess (e.e.) of the (S)-(+)-ethyl-3-hydroxybutanoate 2, obtained in the baker's yeast reduction of ethyl acetoacetate 1, and the concentration of the substrates in the fermentation mixture has been studied by the use of two different techniques (absorbing resins and organic solvents) The presence of resins undoubtedly influences the enantiomeric excess of the product. (C) 1997 Elsevier Science Ltd.

引用

页码：2375 / 2379

页数：5

共 16 条

[1] APPLICATION OF A PRACTICAL BIOCATALYTIC REDUCTION TO AN ENANTIOSELECTIVE SYNTHESIS OF THE 5H-2,3-BENZODIAZEPINE LY300164
ANDERSON, BA
HANSEN, MM
HARKNESS, AR
HENRY, CL
VICENZI, JT
ZMIJEWSKI, MJ
[J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1995, 117 (49) : 12358 - 12359
[2] STEREOCHEMICAL CONTROL OF YEAST REDUCTIONS .2. QUANTITATIVE TREATMENT OF THE KINETICS OF COMPETING ENZYME-SYSTEMS FOR A SINGLE SUBSTRATE
CHEN, CS
ZHOU, BN
GIRDAUKAS, G
SHIEH, WR
VANMIDDLESWORTH, F
GOPALAN, AS
SIH, CJ
[J]. BIOORGANIC CHEMISTRY, 1984, 12 (02) : 98 - 117
[3] LARGE-SCALE PREPARATION OF (S)-ETHYL 3-HYDROXYBUTANOATE WITH A HIGH ENANTIOMERIC EXCESS THROUGH BAKERS YEAST-MEDIATED BIOREDUCTION
KOMETANI, T
YOSHII, H
KITATSUJI, E
NISHIMURA, H
MATSUNO, R
[J]. JOURNAL OF FERMENTATION AND BIOENGINEERING, 1993, 76 (01): : 33 - 37
[4] Kula M.R., 1994, P CHIR EUR 1994 S, P27
[5] Liese A, 1996, BIOTECHNOL BIOENG, V51, P544, DOI 10.1002/(SICI)1097-0290(19960905)51:5<544::AID-BIT6>3.0.CO
[6] 2-C
[7] IMPROVEMENT OF ENANTIOSELECTIVITY OF MICROBIAL REDUCTION BY USING ORGANIC-SOLVENT REDOX COUPLER SYSTEM
NAKAMURA, K
INOUE, Y
OHNO, A
[J]. TETRAHEDRON LETTERS, 1995, 36 (02) : 265 - 266
[8] STEREOCHEMICAL CONTROL IN MICROBIAL REDUCTION .6. STEREOCHEMICAL CONTROL ON YEAST REDUCTION OF ALPHA-KETO ESTERS - REDUCTION BY IMMOBILIZED BAKERS-YEAST IN HEXANE
NAKAMURA, K
INOUE, K
USHIO, K
OKA, S
OHNO, A
[J]. JOURNAL OF ORGANIC CHEMISTRY, 1988, 53 (11) : 2589 - 2593
[9] STEREOCHEMICAL CONTROL IN MICROBIAL REDUCTIONS .20. BIOACTIVE MARINE METABOLITES SERIES .39. REDUCTION BY BAKERS-YEAST IN BENZENE
NAKAMURA, K
KONDO, S
KAWAI, Y
OHNO, A
[J]. TETRAHEDRON LETTERS, 1991, 32 (48) : 7075 - 7078
[10] STEREOCHEMICAL CONTROL IN MICROBIAL REDUCTION .5. EFFECT OF ALLYL ALCOHOL ON REDUCTION OF BETA-KETO-ESTERS BY BAKERS-YEAST
NAKAMURA, K
INOUE, K
USHIO, K
OKA, S
OHNO, A
[J]. CHEMISTRY LETTERS, 1987, (04) : 679 - 682

← 1 2 →