Antimalarial compounds from the root bark of Garcinia polyantha Olv.

被引：18

作者：

Lannang, Alain Meli ^{[2
]}

Louh, Gabin Nselapi ^{[2
]}

Lontsi, David ^{[2
]}

Specht, Sabine ^{[3
]}

Sarite, Salem Ramadan ^{[3
]}

Floerke, Ulrich ^{[1
]}

Hussain, Hidayat ^{[1
]}

Hoerauf, Achim ^{[3
]}

Krohn, Karsten ^{[1
]}

机构：

[1] Univ Gesamthsch Paderborn, Dept Chem, D-33098 Paderborn, Germany

[2] Univ Yaounde, Dept Organ Chem, Yaounde, Cameroon

[3] Univ Hosp Bonn, Inst Med Microbiol Immunol & Parasitol, D-53105 Bonn, Germany

来源：

JOURNAL OF ANTIBIOTICS | 2008年 / 61卷 / 08期

关键词：

Garcinia polyantha; garciniaxanthone I; X-ray crystallography; xanthones; antimalarial activity;

D O I：

10.1038/ja.2008.70

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Eight compounds were isolated from the roots of Garcinia polyantha, and identified. Two of them, the xanthone garciniaxanthone 1 (1), and the triterpene, named garcinane (2), are reported as ne,v natural products. The structures of the new compounds were elucidated oil the basis of 1D and 2D NMR spectroscopic studies. The structure of compound 1 was confirmed by X-ray crystallography. Among the remaining six known compounds, three were known xanthones [smeathxanthone A (3), smeathxanthone B (4), and chefouxanthone (5)], one benzophenone [isoxanthochymol (6)], one triterpene [magnificol], and one sterol [beta-sitosterol]. The in vitro antimalarial activity of isoxanthochymol (6) against Plasmodium falciparum shows strong chemosuppression of parasitic growth.

引用

页码：518 / 523

页数：6

共 26 条

[11] Bangangxanthone A and B, two xanthones from the stem bark of Garcinia polyantha Oliv. [J].