Dynamic regulatory interactions of Polycomb group genes:: MEDEA autoregulation is required for imprinted gene expression in Arabidopsis

被引:118
作者
Baroux, U
Gagliardini, V
Page, DR
Grossniklaus, U
机构
[1] Univ Zurich, Inst Plant Biol, CH-8008 Zurich, Switzerland
[2] Univ Zurich, Zurich Basel Plant Sci Ctr, CH-8008 Zurich, Switzerland
关键词
Arabidopsis; genomic imprinting; MEDEA; Polycomb group; regulation; seed development;
D O I
10.1101/gad.378106
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
The imprinted Arabidopsis Polycomb group (PcG) gene MEDEA (MEA), which is homologous to Enhancer of Zeste [E(Z)], is maternally required for normal seed development. Here we show that, unlike known mammalian imprinted genes, MEA regulates its own imprinted expression: It down-regulates the maternal allele around fertilization and maintains the paternal allele silent later during seed development. Autorepression of the maternal MEA allele is direct and independent of the MEA-FIE (FERTILIZATION-INDEPENDENT ENDOSPERM) PcG complex, which is similar to the E(Z)-ESC (Extra sex combs) complex of animals, suggesting a novel mechanism. A complex network of cross-regulatory interactions among the other known members of the MEA-FIE PcG complex implies distinct functions that are dynamically regulated during reproduction.
引用
收藏
页码:1081 / 1086
页数:6
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