Programmed cell death-2 isoform1 is ubiquitinated by parkin and increased in the substantia nigra of patients with autosomal recessive Parkinson's disease

被引：25

作者：

Fukae, Jiro ^{[1
]}

Sato, Shigeto ^{[1
]}

Shiba, Kahori ^{[2
]}

Sato, Ken-ichi ^{[1
]}

Mori, Hideo ^{[1
]}

Sharp, Philip A. ^{[3
]}

Mizuno, Yoshikuni ^{[2
]}

Hattori, Nobutaka ^{[1
]}

机构：

[1] Juntendo Univ, Sch Med, Dept Neurol, Bunkyo Ku, Tokyo 1138421, Japan

[2] Juntendo Univ, Sch Med, Res Inst Dis Old Ages, Tokyo, Japan

[3] MIT, Ctr Canc Res, Dept Biol, Cambridge, MA 02139 USA

来源：

FEBS LETTERS | 2009年 / 583卷 / 03期

关键词：

Parkin; PDCD2-1; Apoptosis; Ubiquitin-proteasome system; Substantia nigra; S-NITROSYLATION; GENE; PDCD2; APOPTOSIS; LIGASE;

D O I：

10.1016/j.febslet.2008.12.055

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Mutations in parkin gene are responsible for autosomal recessive Parkinson's disease (ARPD) and its loss-of-function is assumed to affect parkin ubiquitin ligase activity. Accumulation of its substrate may induce dopaminergic neurodegeneration in the substantia nigra (SN) of ARPD. Here, we show that parkin interacts with programmed cell death-2 isoform 1 (PDCD2-1) and promotes its ubiquitination. Furthermore, accumulation of PDCD2-1 was found in the SN of ARPD as well as in sporadic PD, suggesting that common failure of the ubiquitin-proteasome system is associated with neuronal death in both ARPD and sporadic PD.

引用

页码：521 / 525

页数：5

共 14 条

[1] The human programmed cell death-2 (PDCD2) gene is a target of BCL6 repression:: Implications for a role of BCL6 in the down-regulation of apoptosis [J].

Baron, BW ;

Anastasi, J ;

Thirman, MJ ;

Furukawa, Y ;

Fears, S ;

Kim, DC ;

Simone, F ;

Birkenbach, M ;

Montag, A ;

Sadhu, A ;

Zeleznik-Le, N ;

McKeithan, TW .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2002, 99 (05) :2860-2865

[2] Overexpression of the PDCD2-like gene results in Inhibited TNF-α production in activated Daudi cells [J].

Chen, Q. ;

Yan, C. -Q. ;

Liu, F. -J. ;

Tong, J. ;

Miao, S. -L. ;

Chen, J. -P. .

HUMAN IMMUNOLOGY, 2008, 69 (4-5) :259-265

[3] Cloning of cDNAs with PDCD2_C domain and their expressions during apoptosis of HEK293T cells [J].

Chen, Q ;

Qian, KX ;

Yan, CQ .

MOLECULAR AND CELLULAR BIOCHEMISTRY, 2005, 280 (1-2) :185-191

[4] S-nitrosylation of Parkin regulates ubiquitination and compromises Parkin's protective function [J].

Chung, KKK ;

Thomas, B ;

Li, XJ ;

Pletnikova, O ;

Troncoso, JC ;

Marsh, L ;

Dawson, VL ;

Dawson, TM .

SCIENCE, 2004, 304 (5675) :1328-1331

[5] Parkin protects human dopaminergic neuroblastoma cells against dopamine-induced apoptosis [J].

Jiang, HB ;

Ren, Y ;

Zhao, JH ;

Feng, J .

HUMAN MOLECULAR GENETICS, 2004, 13 (16) :1745-1754

[6] ISOLATION AND MAPPING OF A HUMAN GENE (PDCD2) THAT IS HIGHLY HOMOLOGOUS TO RP8, A RAT GENE ASSOCIATED WITH PROGRAMMED CELL-DEATH [J].

KAWAKAMI, T ;

FURUKAWA, Y ;

SUDO, K ;

SAITO, H ;

TAKAMI, S ;

TAKAHASHI, E ;

NAKAMURA, Y .

CYTOGENETICS AND CELL GENETICS, 1995, 71 (01) :41-43

[7] Mutations in the parkin gene cause autosomal recessive juvenile parkinsonism [J].

Kitada, T ;

Asakawa, S ;

Hattori, N ;

Matsumine, H ;

Yamamura, Y ;

Minoshima, S ;

Yokochi, M ;

Mizuno, Y ;

Shimizu, N .

NATURE, 1998, 392 (6676) :605-608

[8] Common anti-apoptotic roles of parkin and α-synuclein in human dopaminergic cells [J].

Machida, Y ;

Chiba, T ;

Takayanagi, A ;

Tanaka, Y ;

Asanuma, M ;

Ogawa, N ;

Koyama, A ;

Iwatsubo, T ;

Itoh, S ;

Jansen, PH ;

Shimizu, N ;

Tanaka, K ;

Mizuno, Y ;

Hattori, N .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2005, 332 (01) :233-240

[9] Zfrp8, the Drosophila ortholog of PDCD2, functions in lymph gland development and controls cell proliferation [J].

Minakhina, Svetlana ;

Druzhinina, Marina ;

Steward, Ruth .

DEVELOPMENT, 2007, 134 (13) :2387-2396

[10] IDENTIFICATION OF MESSENGER-RNAS ASSOCIATED WITH PROGRAMMED CELL-DEATH IN IMMATURE THYMOCYTES [J].

OWENS, GP ;

HAHN, WE ;

COHEN, JJ .

MOLECULAR AND CELLULAR BIOLOGY, 1991, 11 (08) :4177-4188

← 1 2 →