Mechanisms and Implications of Age-Associated Impaired Innate Interferon Secretion by Dendritic Cells: A Mini-Review

被引：51

作者：

Agrawal, Anshu ^{[1
]}

机构：

[1] Univ Calif Irvine, Dept Med, Div Basic & Clin Immunol, Irvine, CA 92697 USA

来源：

GERONTOLOGY | 2013年 / 59卷 / 05期

关键词：

Dendritic cells Aging; Type I interferon; Type III interferon; I INTERFERON; T-CELLS; IDO; INFLUENZA; PATHWAY; VIRUS;

D O I：

10.1159/000350536

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

030301 [社会学]; 100201 [内科学];

摘要：

Initial secretion of interferons by innate immune cells such as dendritic cells is crucial for protection against infections as well as for alerting and activating the downstream immune responses. The secretion of innate interferons, both type I and type Ill, by dendritic cells is severely impaired in aged subjects. This review focuses on the mechanisms responsible for the reduced interferon secretion by dendritic cells and the role this plays in the increased susceptibility of the elderly to infections, particularly of the respiratory mucosa. Copyright (C) 2013 S. Karger AG, Basel

引用

页码：421 / 426

页数：6

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