The HPA axis in major depression: classical theories and new developments

被引：1362

作者：

Pariante, Carmine M. ^{[2
]}

Lightman, Stafford L. ^{[1
]}

机构：

[1] Univ Bristol, Henry Wellcome Labs Integrat Neurosci & Endocrino, Bristol BS1 3NY, Avon, England

[2] Kings Coll London, Inst Psychiat, Div Psychol Med & Psychiat, Ctr Cellular Basis Behav,James Black Ctr, London SE5 9NU, England

来源：

TRENDS IN NEUROSCIENCES | 2008年 / 31卷 / 09期

基金：

英国医学研究理事会; 英国生物技术与生命科学研究理事会; 英国惠康基金;

关键词：

D O I：

10.1016/j.tins.2008.06.006

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Studies over the last 40 years have demonstrated that hyperactivity of the hypothalamic-pituitary-adrenal axis is one of the most consistent biological findings in major depression psychiatry, but the mechanisms underlying this abnormality are still unclear.

引用

页码：464 / 468

页数：5

共 38 条

[1] Corticosteroids mediate fast feedback of the rat hypothalamic-pituitary-adrenal axis via the mineralocorticoid receptor [J].

Atkinson, Helen C. ;

Wood, Susan A. ;

Castrique, Emma S. ;

Kershaw, Yvonne M. ;

Wiles, Crispin C. R. ;

Lightman, Stafford L. .

AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM, 2008, 294 (06) :E1011-E1022

[2] Increase in concentration of waking salivary cortisol in recovered patients with depression [J].

Bhagwagar, Z ;

Hafizi, S ;

Cowen, PJ .

AMERICAN JOURNAL OF PSYCHIATRY, 2003, 160 (10) :1890-1891

[3] Increased salivary cortisol after waking in depression [J].

Bhagwagar, Z ;

Hafizi, S ;

Cowen, PJ .

PSYCHOPHARMACOLOGY, 2005, 182 (01) :54-57

[4] Polymorphisms in FKBP5 are associated with increased recurrence of depressive episodes and rapid response to antidepressant treatment [J].

Binder, EB ;

Salyakina, D ;

Lichtner, P ;

Wochnik, GM ;

Ising, M ;

Pütz, B ;

Papiol, S ;

Seaman, S ;

Lucae, S ;

Kohli, MA ;

Nickel, T ;

Künzel, HE ;

Fuchs, B ;

Majer, M ;

Pfennig, A ;

Kern, N ;

Brunner, J ;

Modell, S ;

Baghai, T ;

Deiml, T ;

Zill, P ;

Bondy, B ;

Rupprecht, R ;

Messer, T ;

Köhnlein, O ;

Dabitz, H ;

Brückl, T ;

Müller, N ;

Pfister, H ;

Lieb, R ;

Mueller, JC ;

Lohmussaar, E ;

Strom, TM ;

Bettecken, T ;

Meitinger, T ;

Uhr, M ;

Rein, T ;

Holsboer, F ;

Muller-Myhsok, B .

NATURE GENETICS, 2004, 36 (12) :1319-1325

[5] Influence of child abuse on adult depression - Moderation by the corticotropin-releasing hormone receptor gene [J].

Bradley, Rebekah G. ;

Binder, Elisabeth B. ;

Epstein, Michael P. ;

Tang, Yilang ;

Nair, Hemu P. ;

Liu, Wei ;

Gillespie, Charles F. ;

Berg, Tiina ;

Evces, Mark ;

Newport, D. Jeffrey ;

Stowe, Zachary N. ;

Heim, Christine M. ;

Nemeroff, Charles B. ;

Schwartz, Ann ;

Cubells, Joseph F. ;

Ressler, Kerry J. .

ARCHIVES OF GENERAL PSYCHIATRY, 2008, 65 (02) :190-200

[6]

CARVALHO LA, NEUROPSYCHO IN PRESS

[7] Influence of life stress on depression: Moderation by a polymorphism in the 5-HTT gene [J].

Caspi, A ;

Sugden, K ;

Moffitt, TE ;

Taylor, A ;

Craig, IW ;

Harrington, H ;

McClay, J ;

Mill, J ;

Martin, J ;

Braithwaite, A ;

Poulton, R .

SCIENCE, 2003, 301 (5631) :386-389

[8] Mice that under- or overexpress glucocorticoid receptors as models for depression or posttraumatic stress disorder [J].

Chourbaji, Sabine ;

Vogt, Miriam A. ;

Gass, Peter .

STRESS HORMONES AND POST TRAUMATIC STRESS DISORDER: BASIC STUDIES AND CLINICAL PERSPECTIVES, 2007, 167 :65-+

[9] Proteasome-dependent down-regulation of activated nuclear hippocampal glucocorticoid receptors determines dynamic responses to corticosterone [J].

Conway-Campbell, Becky L. ;

McKenna, Mervyn A. ;

Wiles, Crispin C. ;

Atkinson, Helen C. ;

de Kloet, E. Ron ;

Lightman, Stafford L. .

ENDOCRINOLOGY, 2007, 148 (11) :5470-5477

[10] Childhood maltreatment predicts adult inflammation in a life-course study [J].

Danese, Andrea ;

Pariante, Carmine M. ;

Caspi, Avshalom ;

Taylor, Alan ;

Poulton, Richie .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2007, 104 (04) :1319-1324

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