Use of a racemic derivatizing agent for measurement of enantiomeric excess by circular dichroism spectroscopy

被引：25

作者：

Hattori, T

Minato, Y

Yao, SL

Finn, MG

Miyano, S

机构：

[1] Tohoku Univ, Grad Sch Engn, Dept Biomol Engn, Aoba Ku, Sendai, Miyagi 9808579, Japan

[2] Scripps Res Inst, Dept Chem, La Jolla, CA 92037 USA

来源：

TETRAHEDRON LETTERS | 2001年 / 42卷 / 45期

关键词：

D O I：

10.1016/S0040-4039(01)01707-5

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Enantiomeric excesses of several alcohols and an amine have been determined by derivatization with racemic 2'-methoxy-1,1'-binaphthyl-2-carbonyl chloride rac-1, with no requirement for kinetic resolution in the acylation step. The necessary information is provided instead by CD and UV spectra of the derived esters and amides, the chiral signal being dominated by the binaphthyl component. (C) 2001 Elsevier Science Ltd. All rights reserved.

引用

页码：8015 / 8018

页数：4

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