Microalbuminuria, an integrated marker of cardiovascular risk in essential hypertension

被引:93
作者
Pedrinelli, R [1 ]
Dell'Omo, G [1 ]
Di Bello, V [1 ]
Pontremoli, R [1 ]
Mariani, M [1 ]
机构
[1] Univ Pisa, Dipartimento Cardiotoracico, Pisa, Italy
关键词
albuminuria; microalbuminuria; cardiovascular risk factors;
D O I
10.1038/sj.jhh.1001316
中图分类号
R6 [外科学];
学科分类号
1002 ; 100210 ;
摘要
This paper reviews the existing epidemiological and clinical evidence about the relationships of non-diabetic microalbuminuria with cardiovascular risk factors such as elevated blood pressure (BP), systolic particularly, cardiac hypertrophy, adverse metabolic status, smoking habits, elevated angiotensin II levels, endothelial dysfunction, acute and perhaps subclinical inflammation. Because of that unique property of reflecting the influence of so many clinically relevant parameters, microalbuminuria may legitimately be defined as an integrated marker of cardiovascular risk, an unique profile among the several prognostic predictors available to stratify risk in hypertensive patients. Recent cohort studies also showed associations with cardiovascular morbidity and mortality independently from conventional atherogenic factors. This behaviour, whose understanding still needs further elucidation, suggests to measure albuminuria and to screen patients at a higher absolute risk in whom preventive treatment is expected to be more beneficial than in those with a lower absolute risk.
引用
收藏
页码:79 / 89
页数:11
相关论文
共 160 条
  • [71] Jensen JS, 2000, DAN MED BULL, V47, P63
  • [72] MICROALBUMINURIA IN YOUNG-ADULTS RELATED TO BLOOD-PRESSURE IN A BIRACIAL (BLACK-WHITE) POPULATION - THE BOGALUSA HEART-STUDY
    JIANG, XZ
    SRINIVASAN, SR
    RADHAKRISHNAMURTHY, B
    DALFERES, ER
    BAO, WH
    BERENSON, GS
    [J]. AMERICAN JOURNAL OF HYPERTENSION, 1994, 7 (09) : 794 - 800
  • [73] Hypertensive nephropathy and the gene for angiotensin-converting enzyme
    Kario, K
    Kanai, N
    Nishiuma, S
    Fujii, T
    Saito, K
    Matsuo, T
    Matsuo, M
    Shimada, K
    [J]. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 1997, 17 (02) : 252 - 256
  • [74] Association of microalbuminuria and atherosclerotic risk factors in non-diabetic subjects in Korea
    Kim, CH
    Kim, HK
    Park, JY
    Park, HS
    Hong, SK
    Park, SW
    Lee, KU
    [J]. DIABETES RESEARCH AND CLINICAL PRACTICE, 1998, 40 (03) : 191 - 199
  • [75] RELATION OF LEFT-VENTRICULAR MASS AND GEOMETRY TO MORBIDITY AND MORTALITY IN UNCOMPLICATED ESSENTIAL-HYPERTENSION
    KOREN, MJ
    DEVEREUX, RB
    CASALE, PN
    SAVAGE, DD
    LARAGH, JH
    [J]. ANNALS OF INTERNAL MEDICINE, 1991, 114 (05) : 345 - 352
  • [76] HYPERINSULINEMIC MICROALBUMINURIA - A NEW RISK INDICATOR FOR CORONARY HEART-DISEASE
    KUUSISTO, J
    MYKKANEN, L
    PYORALA, K
    LAAKSO, M
    [J]. CIRCULATION, 1995, 91 (03) : 831 - 837
  • [77] Transforming growth factor β in hypertensives with cardiorenal damage
    Laviades, C
    Varo, N
    Díez, J
    [J]. HYPERTENSION, 2000, 36 (04) : 517 - 522
  • [78] Renoprotective effect of the angiotensin-receptor antagonist irbesartan in patients with nephropathy due to type 2 diabetes
    Lewis, EJ
    Hunsicker, LG
    Clarke, WR
    Berl, T
    Pohl, MA
    Lewis, JB
    Ritz, E
    Atkins, RC
    Rohde, R
    Raz, I
    [J]. NEW ENGLAND JOURNAL OF MEDICINE, 2001, 345 (12) : 851 - 860
  • [79] MICROALBUMINURIA IN OBESITY
    LOKKEGAARD, N
    HAUPTER, I
    KRISTENSEN, TB
    [J]. SCANDINAVIAN JOURNAL OF UROLOGY AND NEPHROLOGY, 1992, 26 (03): : 275 - 278
  • [80] IMPAIRED RENAL FUNCTIONAL RESERVE AND ALBUMINURIA IN ESSENTIAL-HYPERTENSION
    LOSITO, A
    FORTUNATI, F
    ZAMPI, I
    DELFAVERO, A
    [J]. BRITISH MEDICAL JOURNAL, 1988, 296 (6636) : 1562 - 1564